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Cell Adhesion Molecules pp 91–116Cite as

Roles of Nectins and Nectin-Like Molecules in the Nervous System

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Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 8))

Abstract

Nectins are immunoglobulin-like cell adhesion molecules (CAMs) constituting a family with four members. They exclusively localize at adherens junctions (AJs) between two neighboring cells. Nectins bind to afadin through their C-termini and are linked to the actin cytoskeleton. In addition to nectins, there are nectin-like molecules (Necls), which resemble nectins in their structures and constitute a family with five members. Nectins and Necls are involved in the formation of various kinds of cell–cell adhesion and diverse cellular functions including cell polarization, movement, proliferation, survival, and differentiation. In neuronal tissues, nectins and Necls functionally play crucial roles as CAMs at neuron–neuron and neuron–glia interactions. For example, the members of the nectin and Necl families are involved in synapse formation and remodeling in the hippocampus, a key brain region for learning and memory. Nectins also play important roles in the auditory system. Moreover, nectins and Necls are associated with human neurological diseases when mutated or upregulated. Thus, nectins and Necls are crucial for physiology and pathology in the nervous system.

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Acknowledgments

We thank our colleagues and collaborators, for their great contributions and excellent achievements. This work was supported by grants-in-aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Division of Neurophysiology, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan

    Masahiro Mori M.D., Ph.D.

  2. Faculty of Health Sciences, Kobe University Graduate School of Health Sciences, Kobe, Japan

    Masahiro Mori M.D., Ph.D.

  3. CREST, JST, Kobe, Japan

    Masahiro Mori M.D., Ph.D., Yoshiyuki Rikitake M.D., Ph.D., Kenji Mandai M.D., Ph.D. & Yoshimi Takai M.D., Ph.D.

  4. Division of Signal Transduction, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan

    Yoshiyuki Rikitake M.D., Ph.D.

  5. Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

    Yoshiyuki Rikitake M.D., Ph.D.

  6. Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, 650-0047, Japan

    Kenji Mandai M.D., Ph.D. & Yoshimi Takai M.D., Ph.D.

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  1. Masahiro Mori M.D., Ph.D.
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Correspondence to Yoshimi Takai M.D., Ph.D. .

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Editors and Affiliations

  1. Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Vladimir Berezin

  2. Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark

    Peter S. Walmod

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Mori, M., Rikitake, Y., Mandai, K., Takai, Y. (2014). Roles of Nectins and Nectin-Like Molecules in the Nervous System. In: Berezin, V., Walmod, P. (eds) Cell Adhesion Molecules. Advances in Neurobiology, vol 8. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8090-7_5

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