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Transgenerational Epigenetic Effects and Complex Inheritance Patterns

Chapter

Abstract

Mendel’s laws describing the inheritance of simple genetic traits are based on the assumption that genes are transmitted unchanged from parents to offspring. However, this assumption is not always correct as the mammalian genome undergoes massive epigenetic reprogramming during gametogenesis and early embryonic development. Furthermore, stochastic or environmentally induced epigenetic variation may lead to situations where the epigenetic marking of the same allele differs between parents and offspring, among siblings or even monozygotic twins. Epigenetic marks may modify the penetrance of a phenotype and cause “non-Mendelian” inheritance even when the causal genetic variant is transmitted from parent to offspring in perfect Mendelian proportions. In this chapter we focus on a particular type of inheritance where epigenetic marks that are present in parental somatic cells fail to be reset in a proportion of parental germ cells and are transmitted to offspring. Such a transgenerational “epigenetic memory” increases the complexity of the inheritance pattern and therefore is of particular interest for geneticists.

Keywords

Long Terminal Repeat Epigenetic Mark Primordial Germ Cell Epigenetic Reprogram Transmission Ratio Distortion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The author is grateful to Dr. Celia Greenwood, Mary Fujiwara, and Dr. Kenneth Morgan for helpful discussion.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Departments of Obstetrics and Gynecology and Human GeneticsMcGill UniversityMontrealCanada
  2. 2.The Research Institute of the McGill University Health CentreMcGill UniversityMontrealCanada

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