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Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans

  • Janet S. Sinsheimer
  • Michelle M. Creek
Chapter

Abstract

Transgenerational genetic effects occur when the genes of one generation influence the phenotype of subsequent generations without Mendelian transmission of alleles, possibly through inherited epigenetic effects. The evidence for transgenerational genetic effects in humans comes predominantly from genetic epidemiology studies, which thus presents a number of statistical challenges to their analysis and interpretation. In this chapter, we outline some of the genetic epidemiologic study designs and statistical analysis approaches that have been used to detect these effects and discuss their strengths and weaknesses.

Keywords

Assisted Reproductive Technology Transgenerational Effect Transmission Disequilibrium Test Mendelian Randomization Variance Component Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank the editors for their comments on this chapter. This review was supported in part by NIH grants GM53275 and T32-HG002536.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Human GeneticsDavid Geffen School of Medicine at UCLALos AngelesUSA
  2. 2.Department of BiostatisticsUCLA Fielding School of Public HealthLos AngelesUSA

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