Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans
Transgenerational genetic effects occur when the genes of one generation influence the phenotype of subsequent generations without Mendelian transmission of alleles, possibly through inherited epigenetic effects. The evidence for transgenerational genetic effects in humans comes predominantly from genetic epidemiology studies, which thus presents a number of statistical challenges to their analysis and interpretation. In this chapter, we outline some of the genetic epidemiologic study designs and statistical analysis approaches that have been used to detect these effects and discuss their strengths and weaknesses.
KeywordsArthritis Covariance Schizophrenia Stratification Expense
We thank the editors for their comments on this chapter. This review was supported in part by NIH grants GM53275 and T32-HG002536.
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