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Immune Cells in Adipose Tissue: Key Players in Metabolic Disorders

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Angiogenesis in Adipose Tissue

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Abstract

Obesity, defined as an excessive development of adipose tissue, is associated with high risk to develop metabolic disorders including insulin resistance, type 2 diabetes, and cardiovascular diseases. Many investigations performed in mice and humans provided evidences that obesity is associated with a low grade inflammatory state with enhanced both circulating and intra-tissular pro-inflammatory cytokine and chemokine levels as well as accumulation of immune cells, including macrophages and lymphocytes. The inflammatory response that takes place within the adipose tissue during fat mass development remains chronic with obesity and has been identified as the major contributor to its pathogenesis. The present chapter describes the link between immune cells, adipose tissue and obesity-associated pathologies and highlights the role of adipose tissue macrophages in the control of adipose tissue angiogenesis.

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Acknowledgment

The work was supported by fundings from the Fondation pour la recherche médicale, Astra-Zenica, and INSERM.

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Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale (INSERM), Toulouse, France

    Fanny Volat & Anne Bouloumié

  2. Unité Mixte de Recherche (UMR) 1048, Université Paul Sabatier (UPS), Institut de Maladies Métaboliques et Cardiovasculaires (I2MC), 31432, Toulouse Cedex 4, France

    Fanny Volat & Anne Bouloumié

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  1. Fanny Volat
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Correspondence to Anne Bouloumié .

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  1. Microbiology, Tumor and Cell biology (MT, Karolinska Institutet, Stockholm, Sweden

    Yihai Cao

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Volat, F., Bouloumié, A. (2013). Immune Cells in Adipose Tissue: Key Players in Metabolic Disorders. In: Cao, Y. (eds) Angiogenesis in Adipose Tissue. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8069-3_11

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