Stem Cell Applications in Retinal Diseases

Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)


In contrast to limbal-conjunctival autograft transplantation (LCAT) which has been mainstay of treatment for some ocular surface diseases for decades, stem cell therapy (SCT) is still in its infancy stage in the retina clinic today. Currently, there is an unmet need for treatment of most of the retinal disease with blinding outcome. Recent advances in stem cell (SC) technology provide the basis for optimism for the development of SC-based curative strategies to treat retinal blindness. Beginning in mid-2011, FDA-approved clinical protocols using human embryonic stem cell (hESC)-derived RPE for both dry age-related macular degeneration (AMD) and Stargardt macular dystrophy (SMD) are underway. There are, however, several important challenges even from basic molecular mechanisms which need to be overcome in order for SCT to be a viable option for physicians. This article constitutes an up-to-date summary of therapeutic use of SCs, and aims to contribute understanding of the current and potential use of SCT in the retina.


Retina Macula Degeneration Dystrophy Experimental Clinical Stem cell Therapy 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of OphthalmologyGülhane Military Medical Academy and Medical SchoolAnkaraTurkey

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