The Rationale and Implementation of Translational Systems Biology as a New Paradigm for the Study of Inflammation
The contents of this book represent a new way of looking at the role of inflammation in the balance between health and disease and present a series of advanced computational methods applied with an awareness of system-level consequences towards an explicit translational goal. Grounded in the fundamentals of scientific investigation, translational systems biology brings with it the reminder that the quest to improve human health involves being able to effectively intervene on the processes that generate health and disease. Furthermore, the foundational properties of inflammation that challenge the traditional and neotraditional research community, namely complexity and nonlinearity of structure and dynamics, also necessarily scale to the level of that community itself. As a result, the implementation of Translational Systems Biology not only provides a pathway towards discovering and engineering new and better therapies for specific disease processes but also represents a therapeutic paradigm shift for an increasingly ailing and insufficient biomedical research structure.
We would like to thank all the authors who have joined us in this book. Our Translational Systems Biology work was supported in part by the National Institutes of Health grants R01GM67240, P50GM53789, R33HL089082, R01HL080926, R01AI080799, R01HL76157, R01DC008290, and UO1DK072146; National Institute on Disability and Rehabilitation Research grant H133E070024; National Science Foundation grant 0830-370-V601; a Shared University Research Award from IBM, Inc.; and grants from the Commonwealth of Pennsylvania, the Pittsburgh Life Sciences Greenhouse, and the Pittsburgh Tissue Engineering Initiative/Department of Defense.