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Modeling Host–Vector–Pathogen Immuno-inflammatory Interactions in Malaria

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Complex Systems and Computational Biology Approaches to Acute Inflammation

Abstract

Half of the global population is at risk for malaria, which results in nearly one million deaths annually, 86 % of which are in children [1]. Plasmodium falciparum, the most important human malaria parasite, is transmitted by female Anopheles mosquitoes. Parasite development in the mosquito begins with the ingestion of blood containing sexualstage gametocytes. Mobile ookinetes penetrate the midgut epithelium 24–36 h later and transform into midgut-bound oocysts within the open circulatory system of the mosquito. Oocysts grow and develop for 10–12 days and then release thousands of sporozoites, which invade the salivary glands and are released during later blood feeding by the mosquito.

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Acknowledgments

This work was supported by NIH grant R01-AI080799.

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Authors and Affiliations

  1. Department of Surgery, University of Pittsburgh, W944 Starzl Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA, 15213, USA

    Yoram Vodovotz Ph.D.

  2. Department of Computational and Systems Biology, University of Pittsburgh, 3088 BST 3, 3501 Fifth Ave, Pittsburgh, PA, 15260, USA

    Nabil Azhar B.S., Natasa Miskov-Zivanov Ph.D. & James R. Faeder Ph.D.

  3. University of Pittsburgh at Bradford, 300 Campus Drive, 103 D Fisher Hall, Bradford, PA, 16701, USA

    Marius Buliga Ph.D.

  4. Department of Surgery, University of Pittsburgh, W943 Biomedical Science Tower, 200 Lothrop St., Pittsburgh, PA, 15213, USA

    Ruben Zamora Ph.D.

  5. Department of Mathematics, University of Pittsburgh, 301 Thackeray Hall, Pittsburgh, PA, 15260, USA

    Bard Ermentrout Ph.D. & Gregory M. Constantine Ph.D.

  6. Department of Medical Microbiology and Immunology, University of California Davis, 3442 Tupper Hall, One Shields Ave., Davis, CA, 95616, USA

    Nazzy Pakpour Ph.D.

  7. Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, 3437 Tupper Hall, One Shields Avenue, Davis, CA, 95616, USA

    Shirley Luckhart M.D.

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  1. Yoram Vodovotz Ph.D.
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  2. Nabil Azhar B.S.
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Correspondence to Nabil Azhar B.S. .

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Editors and Affiliations

  1. University of Pittsburgh Inflammation and Regenerative Modeling, Pittsburgh, Pennsylvania, USA

    Yoram Vodovotz

  2. University of Chicago Medical Center MC 5094, Chicago, Illinois, USA

    Gary An

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Vodovotz, Y. et al. (2013). Modeling Host–Vector–Pathogen Immuno-inflammatory Interactions in Malaria. In: Vodovotz, Y., An, G. (eds) Complex Systems and Computational Biology Approaches to Acute Inflammation. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8008-2_14

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