Lymphocyte-Depleted Hodgkin Lymphoma

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Part of the Atlas of Anatomic Pathology book series (AAP)


Lymphocyte-depleted (LD) Hodgkin lymphoma (HL) is a type of classical HL with a diffuse growth pattern characterized by Reed–Sternberg and Hodgkin (RS + H) cells, often with anaplastic features, and depletion of small lymphocytes. Amorphous fibrosis can be present. LD is the least common type of HL, representing less than 1 % of cases, and many cases once considered as LD in the past are classified currently as diffuse large B-cell lymphoma, anaplastic large cell lymphoma, or nodular sclerosis HL with LD. LDHL is more frequent in poor countries and in patients with human immunodeficiency virus (HIV) infection. Patients with LD are older, with a median age in the fifth decade, and a male to female ratio of approximately 2–1. Whites and blacks are equally affected. Most patients have advanced clinical stage disease and B symptoms. Although patients with LD have the most aggressive form of all types of HL, in the modern era of chemotherapy patients with LD respond similarly to patients with other types of HL and the 5-year survival among different types of CHL is uniform.


Human Immunodeficiency Virus Overall Survival Hodgkin Lymphoma Anaplastic Large Cell Lymphoma Small Lymphocyte 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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