Solitary Plasmacytoma of Lymph Node
Solitary plasmacytoma of lymph node is a plasma cell neoplasm that involves the lymph node and no other sites of disease. Solitary plasmacytoma is an uncommon plasma cell neoplasm that most often involves bone or other extraosseous sites. Plasmacytoma involving bone is associated with a high risk of concurrent or subsequent plasma cell myeloma. By contrast, extraosseous plasmacytoma is generally an indolent disease with a low risk of progression to plasma cell myeloma.
Lymph nodes are uncommonly involved by plasma cell neoplasms. Most often, a plasma cell neoplasm in lymph node is a manifestation of involvement by plasma cell myeloma. Less often, lymph nodes draining an extraosseous plasmacytoma can be involved by disease. The latter has been reported mostly in association with extramedullary plasmacytoma in the head and neck region. Solitary (primary) plasmacytoma of lymph nodes is a rare variant of extramedullary plasmacytoma and rarely, if ever, progresses to plasma cell myeloma. Although most patients reported with lymph node plasmacytoma have been adults, Shao and colleagues described a series of immunoglobin A (IgA) plasmacytomas characterized by younger age at presentation, evidence of immune dysfunction, frequent lymph node involvement, and low risk of progression to plasma cell myeloma.
KeywordsLymphoma Germinal Myeloma Plasmacytoma Macroglobulinemia