T-Lymphoblastic Lymphoma/Leukemia

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Part of the Atlas of Anatomic Pathology book series (AAP)


T-lymphoblastic lymphoma/leukemia (T-LBL) is a neoplasm of immature lymphoid cells (lymphoblasts) committed to the T-cell lineage. The disease usually presents as an extramedullary tumor mass in the anterior mediastinum or lymph nodes (T-LBL). A smaller subset of patients present with predominant blood and bone marrow involvement (T-lymphoblastic leukemia [T-ALL]). Patients who present as T-LBL often convert to a T-ALL clinical picture over time. This clinical overlap, as well as overlap in immunophenotypic and molecular features, led the authors of the World Health Organization (WHO) classification to combine T-ALL and T-LBL cases into one category. There are some immunophenotypic and molecular differences between T-ALL and T-LBL, however, that may explain their different clinical presentations. Here we focus on patients presenting as T-LBL.


Bone Marrow Involvement Superior Vena Cava Syndrome Peripheral Blood Involvement Conventional Cytogenetic Study Lineage Infidelity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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