T-Lymphoblastic Lymphoma/Leukemia

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Chapter
Part of the Atlas of Anatomic Pathology book series (AAP)

Abstract

T-lymphoblastic lymphoma/leukemia (T-LBL) is a neoplasm of immature lymphoid cells (lymphoblasts) committed to the T-cell lineage. The disease usually presents as an extramedullary tumor mass in the anterior mediastinum or lymph nodes (T-LBL). A smaller subset of patients present with predominant blood and bone marrow involvement (T-lymphoblastic leukemia [T-ALL]). Patients who present as T-LBL often convert to a T-ALL clinical picture over time. This clinical overlap, as well as overlap in immunophenotypic and molecular features, led the authors of the World Health Organization (WHO) classification to combine T-ALL and T-LBL cases into one category. There are some immunophenotypic and molecular differences between T-ALL and T-LBL, however, that may explain their different clinical presentations. Here we focus on patients presenting as T-LBL.

Keywords

Lactate Tyrosine Leukemia CD117 Cough 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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