Reactive Paracortical Hyperplasia

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Chapter
Part of the Atlas of Anatomic Pathology book series (AAP)

Abstract

Reactive—or diffuse—paracortical hyperplasia (RPH) is characterized by expansion of the paracortical areas of the lymph node. The paracortical/interfollicular zone is rich in T-cells associated with interdigitating dendritic cells and histiocytes. The paracortical zone can undergo expansion in response to inflammatory and immune reactions that trigger a T-cell response. Possible etiologies of RPH include infectious agents, vaccine administration, immunodysregulatory diseases, and therapeutic drugs. The most common viruses that cause RPH include herpes simplex virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). In a subset of patients with RPH, no etiology is apparent.

Keywords

Herpes Simplex Virus Anaplastic Large Cell Lymphoma Small Lymphocyte Vaccine Administration Littoral Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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