Reactive Paracortical Hyperplasia

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Part of the Atlas of Anatomic Pathology book series (AAP)


Reactive—or diffuse—paracortical hyperplasia (RPH) is characterized by expansion of the paracortical areas of the lymph node. The paracortical/interfollicular zone is rich in T-cells associated with interdigitating dendritic cells and histiocytes. The paracortical zone can undergo expansion in response to inflammatory and immune reactions that trigger a T-cell response. Possible etiologies of RPH include infectious agents, vaccine administration, immunodysregulatory diseases, and therapeutic drugs. The most common viruses that cause RPH include herpes simplex virus (HSV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). In a subset of patients with RPH, no etiology is apparent.


Herpes Simplex Virus Anaplastic Large Cell Lymphoma Small Lymphocyte Vaccine Administration Littoral Cell 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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