Abstract
Multicentric Castleman disease (MCD) is a rare, systemic lymphoproliferative disorder associated with human herpesvirus 8 (HHV8) infection. Patients present with lymphadenopathy and systemic symptoms including fever, night sweats, and weight loss. The disease commonly involves peripheral and abdominal lymph nodes as well as the spleen and liver. Laboratory studies often demonstrate elevation in erythrocyte sedimentation rate, C-reactive protein, serum lactate dehydrogenase, and IL-6. Cytopenias, especially anemia and thrombocytopenia, may be present also. Most patients with MCD patients have human immunodeficiency virus (HIV) infection, but a subset of patients have POEMS syndrome (peripheral neuropathy, organomegaly, endocrinopathy, monoclonal M protein, skin lesions) and rare patients have neither HIV infection nor POEMS syndrome.
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Miranda, R.N., Khoury, J.D., Medeiros, L.J. (2013). Multicentric Castleman Disease. In: Atlas of Lymph Node Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7959-8_27
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DOI: https://doi.org/10.1007/978-1-4614-7959-8_27
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