Brucellosis Lymphadenitis

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Part of the Atlas of Anatomic Pathology book series (AAP)


Brucellosis lymphadenitis is a systemic bacterial infection caused by Brucella species. Brucellosis (or Malta fever) is one of the most common zoonotic infections in the world. Brucellosis is caused by gram-negative coccobacilli that are members of the Brucella species. The name of the species is derived from David Bruce, who in 1887 was the first to show that these organisms cause disease. There are many members of the Brucella species, but the most common are abortus, melitensis, suis, ovis, canis, neotomae, and microti. The disease is most commonly transmitted to humans through ingestion of raw unpasteurized dairy products or meat derived from domestic livestock. The disease is transmitted via inhalation or direct entry through skin wounds or mucous membranes and is commonly seen in high-risk populations, such as workers in slaughterhouses or meat-packing facilities and veterinarians. In humans, Brucella species can cause a variety of nonspecific systemic symptoms that include arthralgia, fever, malaise, and anorexia. Neurologic symptoms, hepatomegaly, splenomegaly, and/or lymphadenopathy may be detected in a subset of patients. Successful control and eradication efforts through vaccination were implemented in several countries over the past several decades and have helped reduce the burden of brucellosis in livestock.


Mucous Membrane Skin Wound Successful Control Domestic Livestock Direct Entry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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