Bacillary Angiomatosis of Lymph Nodes

  • Roberto N. Miranda
  • Joseph D. Khoury
  • L. Jeffrey Medeiros
Part of the Atlas of Anatomic Pathology book series (AAP)


Bacillary angiomatosis of lymph nodes is a benign tumor-like microvascular proliferation caused by the bacterium Bartonella henselae. Bacillary angiomatosis is commonly associated with immunodeficiency, acquired usually through infection by human immunodeficiency virus (HIV) but rarely caused by other acquired conditions (eg, chronic lymphocytic leukemia/small lymphocytic lymphoma, solid organ transplantation) that compromise the immune system. Bacillary angiomatosis can involve any organ, but skin is the most common site. Epidemiologic data has linked bacillary angiomatosis to exposure to domestic cats that acquire the infection through a flea vector and constitute a reservoir for Bartonella henselae. A gram-negative bacillus, Bartonella henselae is the etiologic agent of several diseases in immunocompetent and immunocompromised individuals, including cat-scratch disease, peliosis hepatis, and endocarditis. Whereas the bacterium causes bacillary angiomatosis almost exclusively in HIV-positive individuals, infection leads to cat-scratch disease, a necrotizing granulomatous inflammatory lymphadenitis, in HIV-negative and apparently immunocompetent individuals.


Human Immunodeficiency Virus Factor VIII Etiologic Agent Solid Organ Transplantation Nuclear Pleomorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Tappero JW, Mohle-Boetani J, Koehler JE, et al. The epidemiology of bacillary angiomatosis and bacillary peliosis. JAMA. 1993;269:770–5.PubMedCrossRefGoogle Scholar
  2. 2.
    Psarros G, Riddell JT, Gandhi T, et al. Bartonella henselae infections in solid organ transplant recipients: report of 5 cases and review of the literature. Medicine (Baltimore). 2012;91:111–21.CrossRefGoogle Scholar
  3. 3.
    Biswas S, Rolain JM. Bartonella infection: treatment and drug resistance. Future Microbiol. 2010;5:1719–31.PubMedCrossRefGoogle Scholar
  4. 4.
    Jacomo V, Kelly PJ, Raoult D. Natural history of Bartonella infections (an exception to Koch’s postulate). Clin Diagn Lab Immunol. 2002;9:8–18.PubMedGoogle Scholar
  5. 5.
    Regnery RL, Anderson BE, Clarridge 3rd JE, et al. Characterization of a novel Rochalimaea species, R. henselae sp. nov., isolated from blood of a febrile, human immunodeficiency virus-positive patient. J Clin Microbiol. 1992;30:265–74.PubMedGoogle Scholar
  6. 6.
    Koehler JE, Sanchez MA, Garrido CS, et al. Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis. N Engl J Med. 1997;337:1876–83.PubMedCrossRefGoogle Scholar
  7. 7.
    Chan JK, Lewin KJ, Lombard CM, et al. Histopathology of bacillary angiomatosis of lymph node. Am J Surg Pathol. 1991;15:430–7.PubMedCrossRefGoogle Scholar
  8. 8.
    LeBoit PE, Berger TG, Egbert BM, et al. Bacillary angiomatosis. The histopathology and differential diagnosis of a pseudoneoplastic infection in patients with human immunodeficiency virus disease. Am J Surg Pathol. 1989;13:909–20.PubMedCrossRefGoogle Scholar
  9. 9.
    Gasquet S, Maurin M, Brouqui P, et al. Bacillary angiomatosis in immunocompromised patients. AIDS. 1998;12:1793–803.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Roberto N. Miranda
    • 1
  • Joseph D. Khoury
    • 1
  • L. Jeffrey Medeiros
    • 1
  1. 1.Department of HematopathologyThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

Personalised recommendations