Abstract
The clinical presentation of skin manifestations in lupus erythematosus (LE) shows great variety and, thus, has led to the differentiation into LE-specific and LE-non-specific manifestations by histological analysis of skin biopsy specimens. Skin lesions, such as urticarial vasculitis and livedo reticularis, are some of the most common LE-non-specific cutaneous manifestations and are mostly associated with systemic LE (SLE), reflecting potentially serious complications. In contrast, the LE-specific manifestations encompass the various subtypes of cutaneous LE (CLE), which is subdivided into four different categories: acute CLE (ACLE), subacute CLE (SCLE), chronic CLE (CCLE) and intermittent CLE (ICLE). It is commonly accepted that sun exposure can induce and exacerbate skin lesions in patients with all subtypes of CLE, supporting the role of ultraviolet light in the pathogenesis of the disease. This chapter summarises the clinical characteristics of the various cutaneous manifestations in SLE.
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References
Albrecht J, et al. Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus. Lupus. 2004;13:839–49.
Tan EM, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271–7.
Kuhn A, et al. Revised cutaneous lupus erythematosus disease area and severity index (RCLASI): a modified outcome instrument for cutaneous lupus erythematosus. Br J Dermatol. 2010;163:83–92.
Kuhn A, et al. Photosensitivity, phototesting, and photoprotection in cutaneous lupus erythematosus. Lupus. 2010;19:1125–36.
Kuhn A, et al. Photosensitivity in lupus erythematosus. Autoimmunity. 2005;38:519–29.
Kuhn A, et al. Accumulation of apoptotic cells in the epidermis of patients with cutaneous lupus erythematosus after ultraviolet irradiation. Arthritis Rheum. 2006;54:939–50.
Kuhn A, et al. Leitlinien Kutaner Lupus Erythematodes (Entwicklungsstufe 1). In: Korting HC, Callies R, Reusch M, Schlaeger M, Sterry W, editors. Dermatologische Qualitätssicherung: Leitlinien und Empfehlungen. Berlin: ABW Wissenschaftsverlag GmbH; 2009. p. 214–57.
Kuhn A, et al. Clinical manifestations of cutaneous lupus erythematosus. In: Kuhn A, Lehmann P, Ruzicka T, editors. Cutaneous lupus erythematosus. Heidelberg: Springer; 2004. p. 59–92.
Kuhn A, et al. The 100th anniversary of lupus erythematosus tumidus. Autoimmun Rev. 2009;8:441–8.
Schmitt V, et al. Lupus erythematosus tumidus is a separate subtype of cutaneous lupus erythematosus. Br J Dermatol. 2010;162:64–73.
Kuhn A, et al. Phototesting in lupus erythematosus tumidus – review of 60 patients. Photochem Photobiol. 2001;73:532–6.
Kuhn A, et al. Differential diagnosis of dermatological peripheral cutaneous circulatory disorders. In: Müller-Ladner U, editor. Raynaud’s phenomenon and peripheral ischemic syndromes. Bremen: Uni-Med Verlag; 2008. p. 53–71.
Acknowledgments  
We thank P. Wissel, J. Bückmann and Professor T. A. Luger, University Muenster, Germany, for providing the clinical figures and Professor D. Metze, University Muenster, Germany, for providing the histological figures.
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Aringer, M., Kuhn, A. (2014). Skin Manifestations of Systemic Lupus Erythematosus. In: Matucci-Cerinic, M., Furst, D., Fiorentino, D. (eds) Skin Manifestations in Rheumatic Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7849-2_27
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DOI: https://doi.org/10.1007/978-1-4614-7849-2_27
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