Cholesterol and Its Role in Synaptic Transmission
Certain level of membrane cholesterol, which is an abundant constituent of eukaryotic membranes, is very important for normal functioning of a number of membrane proteins involved in synaptic transmission, such as ion channels, pumps, receptors, and transporters, while the alterations in cholesterol content change the property of membranes and the activity of these proteins. Moreover, cholesterol deficiency has been implicated in the pathogenesis of several neurodegenerative disorders.
KeywordsSynaptic Vesicle Cholesterol Content Glutamate Transporter Glutamate Uptake Membrane Cholesterol
- Crockett EL (1998) Cholesterol function in plasma membranes from ectotherms: membrane-specific roles in adaptation to temperature. Am Zool 38:291–304Google Scholar
- Jennings LJ, Xu QW, Firth TA (1999) Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle. Am J Physiol 277:1017–1026Google Scholar