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Cholesterol and Its Role in Synaptic Transmission

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Cholesterol and Presynaptic Glutamate Transport in the Brain

Part of the book series: SpringerBriefs in Neuroscience ((BRIEFSNEUROSCI,volume 12))

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Abstract

Certain level of membrane cholesterol, which is an abundant constituent of eukaryotic membranes, is very important for normal functioning of a number of membrane proteins involved in synaptic transmission, such as ion channels, pumps, receptors, and transporters, while the alterations in cholesterol content change the property of membranes and the activity of these proteins. Moreover, cholesterol deficiency has been implicated in the pathogenesis of several neurodegenerative disorders.

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Authors and Affiliations

  1. Department of Neurochemistry Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine

    Tatiana Borisova

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  1. Tatiana Borisova
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Borisova, T. (2013). Cholesterol and Its Role in Synaptic Transmission. In: Cholesterol and Presynaptic Glutamate Transport in the Brain. SpringerBriefs in Neuroscience, vol 12. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7759-4_2

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