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Tissue Engineering of the Urethra: The Basics, Current Concept, and the Future

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Advanced Male Urethral and Genital Reconstructive Surgery

Part of the book series: Current Clinical Urology ((CCU))

Abstract

Urethral reconstruction can be necessitated by congenital anomalies, infection, trauma, and cancer. In situations where the desired surgical outcome requires tissue substitution, choices have traditionally consisted of autografts of flaps and/or grafts, allografts of homologous or heterologous tissue, or synthetic materials. Unfortunately, however, these options have the potential for complications such as donor site morbidity, rejection, or suboptimal performance. Thus, there is a rationale to support development of “off-the-shelf” tissue substitutes that will allow simplified and durable restoration of urethral form and function.

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Authors and Affiliations

  1. Department of Urology, Wake Forest University Health Sciences, 5th Floor Watlington Hall, Medical Center Blvd., Winston-Salem, NC, 27157, USA

    Ryan P. Terlecki MD & Anthony Atala MD

Authors
  1. Ryan P. Terlecki MD
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  2. Anthony Atala MD
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Correspondence to Anthony Atala MD .

Editor information

Editors and Affiliations

  1. Department of Surgery Division of Urologic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA

    Steven B. Brandes

  2. Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

    Allen F. Morey

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Terlecki, R.P., Atala, A. (2014). Tissue Engineering of the Urethra: The Basics, Current Concept, and the Future. In: Brandes, S., Morey, A. (eds) Advanced Male Urethral and Genital Reconstructive Surgery. Current Clinical Urology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-7708-2_36

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  • DOI: https://doi.org/10.1007/978-1-4614-7708-2_36

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