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Investigating the TLR3 Signaling Dynamics

  • Kumar Selvarajoo
Chapter
Part of the Systems Biology book series (SYSTBIOL, volume 3)

Abstract

Along with TLR-7, -8, and -9, TLR3 is an intracellular member of the Toll-like receptor (TLR) superfamily (see Chap. 3). It plays a crucial role in the mammalian innate immune response against viral attacks by recognizing double-stranded RNA (dsRNA) or its synthetic analogue polyinosinic-polycytidylic acid (poly (I:C)). TLR3 is expressed in several cell types including macrophages, murine embryonic fibroblasts (MEFs), and dendritic cells; however, it has not been detected in B cells, T cells, and NK cells. In contrast to all other TLRs, the TLR3 response is independent of the adaptor protein MyD88. The specificity of the TLR3 response possibly results from the occurrence of an alanine residue in a critical region of its cytoplasmic domain, in contrast to the proline residue utilized by MyD88 found in other TLRs. Thus, TLR3 initiates its response depending only on the adaptor protein TRIF and does not involve TRAM.

Keywords

TLR3 Signaling Response Rule Intermediary Step Murine Embryonic Fibroblast Viral Attack 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Kumar Selvarajoo
    • 1
  1. 1.Institute for Advanced BiosciencesKeio UniversityTsuruokaJapan

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