Spatial Neglect: Not Simply Disordered Attention

Chapter

Abstract

A common consequence of right-sided brain damage is the syndrome of spatial neglect, which is seen in 40–90 % of patients in the acute phase after stroke [1–4]. The disorder is a debilitating one in which patients fail to attend to stimuli in contralesional, left space [5–8]. Patients with neglect typically require assistance with most activities of daily living and often fail to dress or groom the left side of their body, leave food uneaten on the left side of a plate, and bump into obstacles on their left. In this chapter I first describe the “classic” case of neglect before describing recent work painting a more complicated picture of the constellation of deficits making up the syndrome. I will then review the recent debate regarding the critical lesion site for neglect before discussing recent rehabilitation attempts. The past few decades of research has shown that neglect can no longer be characterized simply as a disorder of attention.

Keywords

Tray Dyslexia 

References

  1. 1.
    Bowen A, McKenna K, Tallis RC. Reasons for variability in the reported rate of occurrence of unilateral spatial neglect after stroke. Stroke. 1999;30:1196–202.PubMedCrossRefGoogle Scholar
  2. 2.
    Ringman JM, Saver JL, Woolson RF, Clarke WR, Adams HP. Frequency, risk factors, anatomy, and course of unilateral neglect in an acute stroke cohort. Neurology. 2004;63:468–74.PubMedCrossRefGoogle Scholar
  3. 3.
    Appelros P, Karlsson GM, Seiger A, Nydevik I. Neglect and anosognosia after first-ever stroke: incidence and relationship to disability. J Rehabil Med. 2002;34:215–20.PubMedCrossRefGoogle Scholar
  4. 4.
    Cassidy TP, Lewis S, Gray CS. Recovery from visuospatial neglect in stroke patients. J Neurol Neurosurg Psychiatry. 1998;64:555–7.PubMedCrossRefGoogle Scholar
  5. 5.
    Danckert J, Ferber S. Revisiting unilateral neglect. Neuropsychologia. 2006;44:987–1006.PubMedCrossRefGoogle Scholar
  6. 6.
    Halligan PW, Fink GR, Marshall JC, Vallar G. Spatial cognition: evidence from visual neglect. Trends Cogn Sci. 2003;7:125–33.PubMedCrossRefGoogle Scholar
  7. 7.
    Heilman KM, Watson RT, Valenstein E. Neglect and related disorders. In: Heilman KM, Valenstein E, editors. Clinical Neuropsychology (3rd edition). New York: Oxford University Press; 2003.Google Scholar
  8. 8.
    Mesulam M. A cortical network for directed attention and unilateral neglect. Ann Neurol. 1981;10:309–25.PubMedCrossRefGoogle Scholar
  9. 9.
    Albert ML. A simple test of visual neglect. Neurology. 1973;23:658–64.PubMedCrossRefGoogle Scholar
  10. 10.
    Ogden JA. Anterior-posterior interhemispheric differences in the loci of lesions producing visual hemineglect. Brain Cogn. 1985;4:59–75.PubMedCrossRefGoogle Scholar
  11. 11.
    Wilson B, Cockburn J, Halligan P. Development of a behavioural test of visuospatial neglect. Arch Phys Med Rehabil. 1987;68:98–102.PubMedGoogle Scholar
  12. 12.
    Milner AD. Neglect, extinction, and the cortical streams of visual processing. In: Thier P, Karnath H-O, editors. Parietal lobe contributions to orientation in 3D space. Berlin: Springer; 1997. p. 3–22.Google Scholar
  13. 13.
    Rafal RD. Neglect. In: Parasuraman R, editor. The attentive brain. Cambridge, USA: MIT; 1996. p. 489–526.Google Scholar
  14. 14.
    Karnath HO, Himmelbach M, Küker W. The cortical substrate of visual extinction. Neuroreport. 2003;14:437–42.PubMedCrossRefGoogle Scholar
  15. 15.
    Bisiach E, Luzzatti C. Unilateral neglect of representational space. Cortex. 1978;14:129–33.PubMedCrossRefGoogle Scholar
  16. 16.
    Rode G, Rossetti Y, Boisson D. Prism adaptation improves representational neglect. Neuropsychologia. 2001;39:1250–4.PubMedCrossRefGoogle Scholar
  17. 17.
    Rode G, Rossetti Y, Li L, Boisson D. Improvement of mental imagery after prism exposure in neglect: a case study. Behav Neurol. 1998;11:251–8.PubMedGoogle Scholar
  18. 18.
    Beschin N, Robertson IH. Personal versus extrapersonal neglect: a group study of their dissociation using a reliable clinical test. Cortex. 1997;33:379–84.PubMedCrossRefGoogle Scholar
  19. 19.
    Bisiach E, Perani D, Vallar G, Berti A. Unilateral neglect: personal and extra-personal. Neuropsychologia. 1986;24:759–67.PubMedCrossRefGoogle Scholar
  20. 20.
    Cowey A, Small M, Ellis S. Left visuo-spatial neglect can be worse in far than in near space. Neuropsychologia. 1994;32:1059–66.PubMedCrossRefGoogle Scholar
  21. 21.
    Halligan PW, Marshall JC. Left neglect for near but not far space. Nature. 1991;350:498–500.PubMedCrossRefGoogle Scholar
  22. 22.
    Berti A, Smania N, Allport A. Coding of far and near space in neglect patients. Neuroimage. 2001;14:98–102.CrossRefGoogle Scholar
  23. 23.
    Pegna AJ, Petit L, Caldera-Schnetzer AS, Khateb A, Annoni JM, Sztajzel R, et al. So near yet so far: neglect in far or near space depends on tool use. Ann Neurol. 2001;50:820–2.PubMedCrossRefGoogle Scholar
  24. 24.
    Driver J, Baylis GC, Goodrich SJ, Rafal RD. Axis-based neglect of visual shapes. Neuropsychologia. 1994;32:1353–65.PubMedCrossRefGoogle Scholar
  25. 25.
    Tipper S, Behrmann M. Object-centered not scene-based visual neglect. J Exp Psychol Hum Percept Perform. 1996;22:1261–78.PubMedCrossRefGoogle Scholar
  26. 26.
    Ladavas E, Shallice T, Zanella MT. Preserved semantic access in neglect dyslexia. Neuropsychologia. 1997;35:257–70.PubMedCrossRefGoogle Scholar
  27. 27.
    Miceli G, Capasso R. Word-centred neglect dyslexia: evidence from a new case. Neurocase. 2001;7:221–37.PubMedCrossRefGoogle Scholar
  28. 28.
    Vallar G, Guariglia C, Nico D, Tabossi P. Left neglect dyslexia and the processing of neglected information. J Clin Exp Neuropsychol. 1996;18:733–46.PubMedCrossRefGoogle Scholar
  29. 29.
    Brain WR. Visual disorientation with special reference to lesions of the right cerebral hemisphere. Brain. 1941;64:224–72.Google Scholar
  30. 30.
    Paterson A, Zangwill OL. Disorders of visual space perception associated with lesions of the right cerebral hemisphere. Brain. 1944;67:331–58.CrossRefGoogle Scholar
  31. 31.
    Mattingley JB. In: Code C, Wallesch CW, Joanette Y, et al., editors. Classic cases in neuropsychology. UK: Psychology Press; p. 173–188.Google Scholar
  32. 32.
    Adair JC, Barrett AM. Spatial neglect: clinical and neuroscience review: a wealth of information on the poverty of spatial attention. Ann N Y Acad Sci. 2008;1142:21–43.PubMedCrossRefGoogle Scholar
  33. 33.
    Kerkhoff G. Spatial hemineglect in humans. Prog Neurobiol. 2001;63:1–27.PubMedCrossRefGoogle Scholar
  34. 34.
    Corbetta M, Kincade JM, Shulman GL. Neural systems for visual orienting and their relationships to spatial working memory. J Cogn Neurosci. 2002;14:508–23.PubMedCrossRefGoogle Scholar
  35. 35.
    Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci. 2002;3:201–15.PubMedCrossRefGoogle Scholar
  36. 36.
    Kinsbourne M. A model for the mechanism of unilateral neglect of space. Trans Am Neurol Assoc. 1970;95:143–6.PubMedGoogle Scholar
  37. 37.
    Kinsbourne M. Orienting bias model of unilateral neglect: Evidence from attentional gradients within hemispace. In: Robertson IH, Marshall JC, editors. Unilateral neglect: clinical and experimental studies. Hove: Lawrence Erlbaum; 1993. p. 63–86.Google Scholar
  38. 38.
    Posner MI, Walker JA, Friedrich FA, Rafal RD. Effects of parietal injury on covert orienting of attention. J Neurosci. 1984;4:1863–74.PubMedGoogle Scholar
  39. 39.
    Posner MI, Walker JA, Friedrich FA, Rafal RD. How do the parietal lobes direct covert attention? Neuropsychologia. 1987;25:135–45.PubMedCrossRefGoogle Scholar
  40. 40.
    Levy J, Heller W, Banich MT, Burton LA. Asymmetry of perception in free viewing of chimaeric faces. Brain Cogn. 1983;2:404–19.PubMedCrossRefGoogle Scholar
  41. 41.
    Heller W, Levy J. Perception and expression of emotion in right-handers and left-handers. Neuropsychologia. 1981;19:263–72.PubMedCrossRefGoogle Scholar
  42. 42.
    Demaree HA, Everhart DE, Youngstrom EA, Harrison DW. Brain lateralization of emotional processing: historical roots and a future incorporating “dominance”. Behav Cogn Neurosci Rev. 2005;4:3–20.PubMedCrossRefGoogle Scholar
  43. 43.
    Mattingley JB, Bradshaw JL, Nettleton NC, Bradshaw JA. Can task specific perceptual bias be distinguished from unilateral neglect? Neuropsychologia. 1994;32:805–17.PubMedCrossRefGoogle Scholar
  44. 44.
    Dehaene S. The neural basis of the Weber–Fechner law: a logarithmic mental number line. Trends Cogn Sci. 2003;7:145–7.PubMedCrossRefGoogle Scholar
  45. 45.
    Umiltà C, Priftis K, Zorzi M. The spatial representation of numbers: evidence from neglect and pseudoneglect. Exp Brain Res. 2009;192:561–9.PubMedCrossRefGoogle Scholar
  46. 46.
    Zorzi M, Priftis K, Meneghello F, Marenzi R, Umiltà C. The spatial representation of numerical and non-numerical sequences: evidence from neglect. Neuropsychologia. 2006;44:1061–7.PubMedCrossRefGoogle Scholar
  47. 47.
    Zorzi M, Priftis K, Umiltà C. Brain damage: neglect disrupts the mental number line. Nature. 2002;417:138–9.PubMedCrossRefGoogle Scholar
  48. 48.
    Behrmann M, Ghiselli-Crippa T, Sweeney JA, Di Matteo I, Kass R. Mechanisms underlying spatial representation revealed through studies of hemispatial neglect. J Cogn Neurosci. 2002;14:272–90.PubMedCrossRefGoogle Scholar
  49. 49.
    De Renzi E, Gentilini M, Faglioni P, Barbieri C. Attentional shift towards the rightmost stimuli in patients with left visual neglect. Cortex. 1989;25:231–7.PubMedCrossRefGoogle Scholar
  50. 50.
    Natale E, Marzi CA, Bricolo E, Johannsen L, Karnath HO. Abnormally speeded saccades to ipsilesional targets in patients with spatial neglect. Neuropsychologia. 2007;45:263–72.PubMedCrossRefGoogle Scholar
  51. 51.
    Behrmann M, Watt S, Black SE, Barton JJ. Impaired visual search in patients with unilateral neglect: an oculographic analysis. Neuropsychologia. 1997;35:1445–58.PubMedCrossRefGoogle Scholar
  52. 52.
    Bartolomeo P, Chokron S. Orienting of attention in left unilateral neglect. Neurosci Biobehav Rev. 2002;26:217–34.PubMedCrossRefGoogle Scholar
  53. 53.
    Losier BJ, Klein RM. A review of the evidence for a disengage deficit following parietal lobe damage. Neurosci Biobehav Rev. 2001;25:1–13.PubMedCrossRefGoogle Scholar
  54. 54.
    Robertson IH, Manly T, Beschin N, Daini R, Haeske-Dewick H, Hömberg V, et al. Auditory sustained attention is a marker of unilateral spatial neglect. Neuropsychologia. 1997;35:1527–32.PubMedCrossRefGoogle Scholar
  55. 55.
    Robertson IH, Tegnér R, Tham K, Lo A, Nimmo-Smith I. Sustained attention training for unilateral neglect: theoretical and rehabilitation implications. J Clin Exp Neuropsychol. 1995;17:416–30.PubMedCrossRefGoogle Scholar
  56. 56.
    Robertson IH, Ward A, Ridgeway V, Nimmo-Smith I. Test of everyday attention. Flempton: Thames Valley Test Company; 1994.Google Scholar
  57. 57.
    Robertson IH, Ward T, Ridgeway V, Nimmo-Smith I. The structure of normal human attention: the Test of Everyday Attention. J Int Neuropsychol Soc. 1996;2:525–34.PubMedCrossRefGoogle Scholar
  58. 58.
    Husain M, Nachev P. Space and the parietal cortex. Trends Cogn Sci. 2007;11:30–6.PubMedCrossRefGoogle Scholar
  59. 59.
    Husain M, Rorden C. Non-spatially lateralised mechanisms in hemispatial neglect. Nat Rev Neurosci. 2003;4:26–36.PubMedCrossRefGoogle Scholar
  60. 60.
    Robertson IH. Do we need the “lateral” in unilateral neglect? Spatially non-selective attention deficits in unilateral neglect and their implications for rehabilitation. Neuroimage. 2001;14:S85–90.PubMedCrossRefGoogle Scholar
  61. 61.
    Robertson IH, Mattingley JB, Rorden C, Driver J. Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness. Nature. 1998;395:169–72.PubMedCrossRefGoogle Scholar
  62. 62.
    Husain M, Shapiro K, Martin J, Kennard C. Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature. 1997;385:154–6.PubMedCrossRefGoogle Scholar
  63. 63.
    Chun MM, Potter MC. A two-stage model for multiple target detection in rapid serial visual presentation. J Exp Psychol Hum Percept Perform. 1995;21:109–27.PubMedCrossRefGoogle Scholar
  64. 64.
    Raymond JE, Shapiro KL, Arnell KM. Temporary suppression of visual processing in an RSVP task: an attentional blink? J Exp Psychol Hum Percept Perform. 1992;18:849–60.PubMedCrossRefGoogle Scholar
  65. 65.
    Livesey EJ, Harris IM. Target sparing effects in the attentional blink depend on type of stimulus. Atten Percept Psychophys. 2011;73:2104–23.PubMedCrossRefGoogle Scholar
  66. 66.
    Shapiro K, Hillstrom AP, Husain M. Control of visuotemporal attention by inferior parietal and superior temporal cortex. Curr Biol. 2002;12:1320–5.PubMedCrossRefGoogle Scholar
  67. 67.
    Rizzo M, Akutsu H, Dawson J. Increased attentional blink after focal cerebral lesions. Neurology. 2001;57:795–800.PubMedCrossRefGoogle Scholar
  68. 68.
    Schweizer TA, Alexander MP, Cusimano M, Stuss DT. Fast and efficient visuotemporal attention requires the cerebellum. Neuropsychologia. 2007;45:3068–74.PubMedCrossRefGoogle Scholar
  69. 69.
    Ferber S, Danckert J. Lost in space—the fate of memory representations for non-neglected stimuli. Neuropsychologia. 2006;44:320–5.PubMedCrossRefGoogle Scholar
  70. 70.
    Wojciulik E, Husain M, Clarke K, Driver J. Spatial working memory deficit in unilateral neglect. Neuropsychologia. 2001;39:390–6.PubMedCrossRefGoogle Scholar
  71. 71.
    Wojciulik E, Rorden C, Clarke K, Husain M, Driver J. Group study of an “undercover” test for visuospatial neglect: invisible cancellation can reveal more neglect than standard cancellation. J Neurol Neurosurg Psychiatry. 2004;75:1356–8.PubMedCrossRefGoogle Scholar
  72. 72.
    Parton A, Malhotra P, Nachev P, Ames D, Ball J, Chataway J, et al. Space re-exploration in hemispatial neglect. Neuroreport. 2006;17:833–6.PubMedCrossRefGoogle Scholar
  73. 73.
    Malhotra P, Mannan S, Driver J, Husain M. Impaired spatial working memory: one component of the visual neglect syndrome? Cortex. 2004;40:667–76.PubMedCrossRefGoogle Scholar
  74. 74.
    Basso G, Nichelli P, Frassinetti F, di Pellegrino G. Time perception in a neglected space. Neuroreport. 1996;7:2111–4.PubMedCrossRefGoogle Scholar
  75. 75.
    Danckert J, Ferber S, Pun C, Broderick C, Striemer C, Rock S, et al. Neglected time: impaired temporal perception of multisecond intervals in unilateral neglect. J Cogn Neurosci. 2007;19:1706–20.PubMedCrossRefGoogle Scholar
  76. 76.
    Merrifield C, Hurwitz M, Danckert J. Multimodal temporal perception deficits in a patient with left spatial neglect. Cogn Neurosci. 2010;4:244–53.Google Scholar
  77. 77.
    Becchio C, Bertone C. Time and neglect: abnormal temporal dynamics in unilateral spatial neglect. Neuropsychologia. 2006;44:2775–82.PubMedCrossRefGoogle Scholar
  78. 78.
    Harrington DL, Haaland KY, Knight RT. Cortical networks underlying mechanisms of time perception. J Neurosci. 1998;18:1085–95.PubMedGoogle Scholar
  79. 79.
    Aboulafia-Brakha T, Christe B, Martory MD, Annoni JM. Theory of mind tasks and executive functions: a systematic review of group studies in neurology. J Neuropsychol. 2011;5:39–55.PubMedCrossRefGoogle Scholar
  80. 80.
    Danckert J, Ferber S, Doherty T, Steinmetz H, Nicolle D, Goodale MA. Selective, non-lateralized impairment of motor imagery following right parietal damage. Neurocase. 2002;8:194–204.PubMedGoogle Scholar
  81. 81.
    Sirigu A, Duhamel J, Cohen L, Pillon B, Dubois B, Agid Y. The mental representation of hand movements after parietal cortex damage. Science. 1996;273(5281):1564–8.PubMedCrossRefGoogle Scholar
  82. 82.
    Wolpert DM, Miall RC, Kawato M. Internal models in the cerebellum. Trends Cogn Sci. 1998;2:338–47.PubMedCrossRefGoogle Scholar
  83. 83.
    Wolpert DM, Goodbody SJ, Husain M. Maintaining internal representations: the role of the human superior parietal lobe. Nat Neurosci. 1998;1:529–33.PubMedCrossRefGoogle Scholar
  84. 84.
    Tenenbaum JB, Kemp C, Griffiths TL, Goodman ND. How to grow a mind: statistics, structure, and abstraction. Science. 2011;331:1279–85.PubMedCrossRefGoogle Scholar
  85. 85.
    Pisella L, Mattingley JB. The contribution of spatial remapping to unilateral visual neglect. Neurosci Biobehav Rev. 2004;28:181–200.PubMedCrossRefGoogle Scholar
  86. 86.
    Duhamel JR, Goldberg ME, Fitzgibbon EJ, Sirigu A, Grafman J. Saccadic dysmetria in a patient with a right fronto-parietal lesion: the importance of corollary discharge for accurate spatial behaviour. Brain. 1992;115:1387–402.PubMedCrossRefGoogle Scholar
  87. 87.
    Heide W, Blankenburg M, Zimmermann E, Kömpf D. Cortical control of double-step saccades: implications for spatial orientation. Ann Neurol. 1995;38:739–48.PubMedCrossRefGoogle Scholar
  88. 88.
    Striemer C, Danckert J. Through a prism darkly: re-evaluating prisms and neglect. Trends Cogn Sci. 2010;14:308–16.PubMedCrossRefGoogle Scholar
  89. 89.
    Striemer C, Danckert J. Dissociating perceptual and motor effects of prism adaptation in spatial neglect. Neuroreport. 2010;21:436–41.PubMedCrossRefGoogle Scholar
  90. 90.
    Druker M, Anderson B. Spatial probability AIDS visual stimulus discrimination. Front Hum Neurosci. 2010;4:63.PubMedGoogle Scholar
  91. 91.
    Craik K. The nature of explanation. New York: Cambridge University Press; 1943.Google Scholar
  92. 92.
    Johnson-Laird PN. Mental models and human reasoning. Proc Natl Acad Sci USA. 2010;107:18243–50.PubMedCrossRefGoogle Scholar
  93. 93.
    Blakemore SJ, Goodbody SJ, Wolpert DM. Predicting the consequences of our own actions: the role of sensorimotor context estimation. J Neurosci. 1998;18:7511–8.PubMedGoogle Scholar
  94. 94.
    Desmurget M, Epstein CM, Turner RS, Prablanc C, Alexander GE, Grafton ST. Role of the posterior parietal cortex in updating reaching movements to a visual target. Nat Neurosci. 1999;2:563–7.PubMedCrossRefGoogle Scholar
  95. 95.
    Frith CD, Blakemore SJ, Wolpert DM. Abnormalities in the awareness and control of action. Philos Trans R Soc Lond B Biol Sci. 2000;355:1771–88.PubMedCrossRefGoogle Scholar
  96. 96.
    Danckert J, Stöttinger E, Quehl N, Anderson B. Right hemisphere brain damage impairs strategy updating. Cereb Cortex. 2012;22(12):2745–60. Epub 2011 Dec 15.PubMedCrossRefGoogle Scholar
  97. 97.
    Vallar G, Perani D. The anatomy of unilateral neglect after right hemisphere stroke lesions. A clinical/CT-scan correlation study in man. Neuropsychologia. 1986;24:609–22.PubMedCrossRefGoogle Scholar
  98. 98.
    Karnath HO, Ferber S, Himmelbach M. Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature. 2001;411:950–3.PubMedCrossRefGoogle Scholar
  99. 99.
    Mort DJ, Malhotra P, Mannan SK, Rorden C, Pambakian A, Kennard C, et al. The anatomy of visual neglect. Brain. 2003;126:1986–97.PubMedCrossRefGoogle Scholar
  100. 100.
    Ferber S, Karnath HO. How to assess spatial neglect—line bisection or cancellation tasks? J Clin Exp Neuropsychol. 2001;23:599–607.PubMedCrossRefGoogle Scholar
  101. 101.
    Buxbaum LJ, Ferraro MK, Veramonti T, Farne A, Whyte J, Ladavas E, et al. Hemispatial neglect: subtypes, neuroanatomy, and disability. Neurology. 2004;62:749–56.PubMedCrossRefGoogle Scholar
  102. 102.
    Chechlacz M, Rotshtein P, Bickerton WL, Hansen PC, Deb S, Humphreys GW. Separating neural correlates of allocentric and egocentric neglect: distinct cortical sites and common white matter disconnections. Cogn Neuropsychol. 2010;27:277–303.PubMedCrossRefGoogle Scholar
  103. 103.
    Rorden C, Fruhmann Berger M, Karnath HO. Disturbed line bisection is associated with posterior brain lesions. Brain Res. 2006;1080:17–25.PubMedCrossRefGoogle Scholar
  104. 104.
    Verdon V, Schwartz S, Lovblad KO, Hauert CA, Vuilleumier P. Neuroanatomy of hemispatial neglect and its functional components: a study using voxel-based lesion-symptom mapping. Brain. 2010;133:880–94.PubMedCrossRefGoogle Scholar
  105. 105.
    Bartolomeo P, Thiebaut de Schotten M, Doricchi F. Left unilateral neglect as a disconnection syndrome. Cereb Cortex. 2007;17:2479–90.PubMedCrossRefGoogle Scholar
  106. 106.
    Doricchi F, Thiebaut de Schotten M, Tomaiuolo F, Bartolomeo P. White matter (dis)connections and gray matter (dys)functions in visual neglect: gaining insights into the brain networks of spatial awareness. Cortex. 2008;44:983–95.PubMedCrossRefGoogle Scholar
  107. 107.
    Bird CM, Malhotra P, Parton A, Coulthard E, Rushworth MF, Husain M. Visual neglect following right posterior cerebral artery infarction. J Neurol Neurosurg Psychiatry. 2006;77:1008–12.PubMedCrossRefGoogle Scholar
  108. 108.
    Doricchi F, Tomaiuolo F. The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? Neuroreport. 2003;14:2239–43.PubMedCrossRefGoogle Scholar
  109. 109.
    Thiebaut de Schotten M, Urbanski M, Duffau H, Volle E, Lévy R, Dubois B, et al. Direct evidence for a parietal frontal pathway subserving spatial awareness in humans. Science. 2005;309:2226–8.PubMedCrossRefGoogle Scholar
  110. 110.
    Urbanski M, Thiebaut de Schotten M, Rodrigo S, Oppenheim C, Touzé E, Méder JF, et al. DTI-MR tractography of white matter damage in stroke patients with neglect. Exp Brain Res. 2011;208:491–505.PubMedCrossRefGoogle Scholar
  111. 111.
    Urbanski M, Thiebaut de Schotten M, Rodrigo S, Catani M, Oppenheim C, Touzé E, et al. Brain networks of spatial awareness: evidence from diffusion tensor imaging tractography. J Neurol Neurosurg Psychiatry. 2008;79:598–601.PubMedCrossRefGoogle Scholar
  112. 112.
    Farné A, Buxbaum LJ, Ferraro M, Frassinetti F, Whyte J, Veramonti T, et al. Patterns of spontaneous recovery of neglect and associated disorders in acute right brain-damaged patients. J Neurol Neurosurg Psychiatry. 2004;75:1401–10.PubMedCrossRefGoogle Scholar
  113. 113.
    Adair JC, Na DL, Schwartz RL, Heilman KM. Caloric stimulation in neglect: evaluation of response as a function of neglect type. J Int Neuropsychol Soc. 2003;9:983–8.PubMedCrossRefGoogle Scholar
  114. 114.
    Karnath HO, Christ K, Hartje W. Decrease of contralateral neglect by neck muscle vibration and spatial orientation of trunk midline. Brain. 1993;116:383–96.PubMedCrossRefGoogle Scholar
  115. 115.
    Karnath HO, Fetter M, Dichgans J. Ocular exploration of space as a function of neck proprioceptive and vestibular input: observations in normal subjects and patients with spatial neglect after parietal lesions. Exp Brain Res. 1996;109:333–42.PubMedCrossRefGoogle Scholar
  116. 116.
    Rubens AB. Caloric stimulation and unilateral visual neglect. Neurology. 1985;35:1019–24.PubMedCrossRefGoogle Scholar
  117. 117.
    Eskes GA, Butler B, McDonald A, Harrison ER, Phillips SJ. Limb activation effects in hemispatial neglect. Arch Phys Med Rehabil. 2003;84:323–8.PubMedCrossRefGoogle Scholar
  118. 118.
    Rossi PW, Kheyfets S, Reding MJ. Fresnel prisms improve visual perception in stroke patients with homonymous hemianopia or unilateral visual neglect. Neurology. 1990;40:1597–9.PubMedCrossRefGoogle Scholar
  119. 119.
    Rossetti Y, Rode G, Pisella L, Farné A, Li L, Boisson D, Perenin MT. Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature. 1998;395:166–9.PubMedCrossRefGoogle Scholar
  120. 120.
    Nys GMS, de Haan EHF, Kunneman A, de Kort PL, Dijkerman HC. Acute neglect rehabilitation using repetitive prism adaptation. A randomized placebo-controlled trial. Restor Neurol Neurosci. 2008;26:1–12.PubMedGoogle Scholar
  121. 121.
    Turton AJ, O’Leary K, Gabb J, Woodward R, Gilchrist ID. A single blinded randomised controlled pilot trial of prism adaptation for improving self-care in stroke patients with neglect. Neuropsychol Rehabil. 2010;20:180–96.PubMedCrossRefGoogle Scholar
  122. 122.
    Redding GM, Wallace B. Prism adaptation and unilateral neglect: review and analysis. Neuropsychologia. 2006;44:1–20.PubMedCrossRefGoogle Scholar
  123. 123.
    Pisella L, Rode G, Farné A, Tilikete C, Rossetti Y. Prism adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders. Curr Opin Neurol. 2006;19:534–42.PubMedCrossRefGoogle Scholar
  124. 124.
    Ferber S, Danckert J, Joanisse M, Goltz HC, Goodale MA. Eye movements tell only half the story. Neurology. 2003;60:1826–9.PubMedCrossRefGoogle Scholar
  125. 125.
    Tilikete C, Rode G, Rossetti Y, Pichon J, Li L, Boisson D. Prism adaptation to rightward optical deviation improves postural imbalance in left-hemiparetic patients. Curr Biol. 2001;11:524–8.PubMedCrossRefGoogle Scholar
  126. 126.
    Striemer C, Danckert J. Prism adaptation reduces the disengage deficit in right brain damage patients. Neuroreport. 2007;18:99–103.PubMedCrossRefGoogle Scholar
  127. 127.
    Frassinetti F, Angelini V, Meneghello F, Avanzi S, Làdavas E. Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain. 2002;125:608–23.PubMedCrossRefGoogle Scholar
  128. 128.
    Striemer C, Sablatnig J, Danckert J. Differential influences of prism adaptation on reflexive and voluntary covert attention. J Int Neuropsychol Soc. 2006;12:337–49.PubMedCrossRefGoogle Scholar
  129. 129.
    Nijboer TC, McIntosh RD, Nys GM, Dijkerman HC, Milner AD. Prism adaptation improves voluntary but not automatic orienting in neglect. Neuroreport. 2008;19:293–8.PubMedCrossRefGoogle Scholar
  130. 130.
    Dijkerman HC, McIntosh RD, Milner AD, Rossetti Y, Tilikete C, Roberts RC. Ocular scanning and perceptual size distortion in hemineglect: effects of prism adaptation and sequential stimulus presentation. Exp Brain Res. 2003;153:220–30.PubMedCrossRefGoogle Scholar
  131. 131.
    Goodale MA, Milner AD. Separate visual pathways for perception and action. Trends Neurosci. 1992;15:20–5.PubMedCrossRefGoogle Scholar
  132. 132.
    Karnath HO, Fruhmann-Berger M, Küker W, Rorden C. The anatomy of spatial neglect based on voxelwise statistical analysis: a study of 140 patients. Cereb Cortex. 2004;14:1164–72.PubMedCrossRefGoogle Scholar
  133. 133.
    Karnath HO, Rorden C, Ticini LF. Damage to white matter fiber tracts in acute spatial neglect. Cereb Cortex. 2009;19:2331–7.PubMedCrossRefGoogle Scholar
  134. 134.
    Karnath HO, Rennig J, Johannsen L, Rorden C. The anatomy underlying acute versus chronic spatial neglect: a longitudinal study. Brain. 2011;134:903–12.PubMedCrossRefGoogle Scholar
  135. 135.
    Ptak R, Schnider A. The attention network of the human brain: relating structural damage associated with spatial neglect to functional imaging correlates of spatial attention. Neuropsychologia. 2011;49:3063–70.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of WaterlooWaterlooCanada

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