Skip to main content
SpringerLink
Log in

Spatial Neglect: Not Simply Disordered Attention

  • Chapter
  • First Online:
The Behavioral Consequences of Stroke

Abstract

A common consequence of right-sided brain damage is the syndrome of spatial neglect, which is seen in 40–90 % of patients in the acute phase after stroke [1–4]. The disorder is a debilitating one in which patients fail to attend to stimuli in contralesional, left space [5–8]. Patients with neglect typically require assistance with most activities of daily living and often fail to dress or groom the left side of their body, leave food uneaten on the left side of a plate, and bump into obstacles on their left. In this chapter I first describe the “classic” case of neglect before describing recent work painting a more complicated picture of the constellation of deficits making up the syndrome. I will then review the recent debate regarding the critical lesion site for neglect before discussing recent rehabilitation attempts. The past few decades of research has shown that neglect can no longer be characterized simply as a disorder of attention.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bowen A, McKenna K, Tallis RC. Reasons for variability in the reported rate of occurrence of unilateral spatial neglect after stroke. Stroke. 1999;30:1196–202.

    Article  PubMed  CAS  Google Scholar 

  2. Ringman JM, Saver JL, Woolson RF, Clarke WR, Adams HP. Frequency, risk factors, anatomy, and course of unilateral neglect in an acute stroke cohort. Neurology. 2004;63:468–74.

    Article  PubMed  CAS  Google Scholar 

  3. Appelros P, Karlsson GM, Seiger A, Nydevik I. Neglect and anosognosia after first-ever stroke: incidence and relationship to disability. J Rehabil Med. 2002;34:215–20.

    Article  PubMed  Google Scholar 

  4. Cassidy TP, Lewis S, Gray CS. Recovery from visuospatial neglect in stroke patients. J Neurol Neurosurg Psychiatry. 1998;64:555–7.

    Article  PubMed  CAS  Google Scholar 

  5. Danckert J, Ferber S. Revisiting unilateral neglect. Neuropsychologia. 2006;44:987–1006.

    Article  PubMed  Google Scholar 

  6. Halligan PW, Fink GR, Marshall JC, Vallar G. Spatial cognition: evidence from visual neglect. Trends Cogn Sci. 2003;7:125–33.

    Article  PubMed  Google Scholar 

  7. Heilman KM, Watson RT, Valenstein E. Neglect and related disorders. In: Heilman KM, Valenstein E, editors. Clinical Neuropsychology (3rd edition). New York: Oxford University Press; 2003.

    Google Scholar 

  8. Mesulam M. A cortical network for directed attention and unilateral neglect. Ann Neurol. 1981;10:309–25.

    Article  PubMed  CAS  Google Scholar 

  9. Albert ML. A simple test of visual neglect. Neurology. 1973;23:658–64.

    Article  PubMed  CAS  Google Scholar 

  10. Ogden JA. Anterior-posterior interhemispheric differences in the loci of lesions producing visual hemineglect. Brain Cogn. 1985;4:59–75.

    Article  PubMed  CAS  Google Scholar 

  11. Wilson B, Cockburn J, Halligan P. Development of a behavioural test of visuospatial neglect. Arch Phys Med Rehabil. 1987;68:98–102.

    PubMed  CAS  Google Scholar 

  12. Milner AD. Neglect, extinction, and the cortical streams of visual processing. In: Thier P, Karnath H-O, editors. Parietal lobe contributions to orientation in 3D space. Berlin: Springer; 1997. p. 3–22.

    Google Scholar 

  13. Rafal RD. Neglect. In: Parasuraman R, editor. The attentive brain. Cambridge, USA: MIT; 1996. p. 489–526.

    Google Scholar 

  14. Karnath HO, Himmelbach M, Küker W. The cortical substrate of visual extinction. Neuroreport. 2003;14:437–42.

    Article  PubMed  Google Scholar 

  15. Bisiach E, Luzzatti C. Unilateral neglect of representational space. Cortex. 1978;14:129–33.

    Article  PubMed  CAS  Google Scholar 

  16. Rode G, Rossetti Y, Boisson D. Prism adaptation improves representational neglect. Neuropsychologia. 2001;39:1250–4.

    Article  PubMed  CAS  Google Scholar 

  17. Rode G, Rossetti Y, Li L, Boisson D. Improvement of mental imagery after prism exposure in neglect: a case study. Behav Neurol. 1998;11:251–8.

    PubMed  Google Scholar 

  18. Beschin N, Robertson IH. Personal versus extrapersonal neglect: a group study of their dissociation using a reliable clinical test. Cortex. 1997;33:379–84.

    Article  PubMed  CAS  Google Scholar 

  19. Bisiach E, Perani D, Vallar G, Berti A. Unilateral neglect: personal and extra-personal. Neuropsychologia. 1986;24:759–67.

    Article  PubMed  CAS  Google Scholar 

  20. Cowey A, Small M, Ellis S. Left visuo-spatial neglect can be worse in far than in near space. Neuropsychologia. 1994;32:1059–66.

    Article  PubMed  CAS  Google Scholar 

  21. Halligan PW, Marshall JC. Left neglect for near but not far space. Nature. 1991;350:498–500.

    Article  PubMed  CAS  Google Scholar 

  22. Berti A, Smania N, Allport A. Coding of far and near space in neglect patients. Neuroimage. 2001;14:98–102.

    Article  Google Scholar 

  23. Pegna AJ, Petit L, Caldera-Schnetzer AS, Khateb A, Annoni JM, Sztajzel R, et al. So near yet so far: neglect in far or near space depends on tool use. Ann Neurol. 2001;50:820–2.

    Article  PubMed  CAS  Google Scholar 

  24. Driver J, Baylis GC, Goodrich SJ, Rafal RD. Axis-based neglect of visual shapes. Neuropsychologia. 1994;32:1353–65.

    Article  PubMed  CAS  Google Scholar 

  25. Tipper S, Behrmann M. Object-centered not scene-based visual neglect. J Exp Psychol Hum Percept Perform. 1996;22:1261–78.

    Article  PubMed  CAS  Google Scholar 

  26. Ladavas E, Shallice T, Zanella MT. Preserved semantic access in neglect dyslexia. Neuropsychologia. 1997;35:257–70.

    Article  PubMed  CAS  Google Scholar 

  27. Miceli G, Capasso R. Word-centred neglect dyslexia: evidence from a new case. Neurocase. 2001;7:221–37.

    Article  PubMed  CAS  Google Scholar 

  28. Vallar G, Guariglia C, Nico D, Tabossi P. Left neglect dyslexia and the processing of neglected information. J Clin Exp Neuropsychol. 1996;18:733–46.

    Article  PubMed  CAS  Google Scholar 

  29. Brain WR. Visual disorientation with special reference to lesions of the right cerebral hemisphere. Brain. 1941;64:224–72.

    Google Scholar 

  30. Paterson A, Zangwill OL. Disorders of visual space perception associated with lesions of the right cerebral hemisphere. Brain. 1944;67:331–58.

    Article  Google Scholar 

  31. Mattingley JB. In: Code C, Wallesch CW, Joanette Y, et al., editors. Classic cases in neuropsychology. UK: Psychology Press; p. 173–188.

    Google Scholar 

  32. Adair JC, Barrett AM. Spatial neglect: clinical and neuroscience review: a wealth of information on the poverty of spatial attention. Ann N Y Acad Sci. 2008;1142:21–43.

    Article  PubMed  Google Scholar 

  33. Kerkhoff G. Spatial hemineglect in humans. Prog Neurobiol. 2001;63:1–27.

    Article  PubMed  CAS  Google Scholar 

  34. Corbetta M, Kincade JM, Shulman GL. Neural systems for visual orienting and their relationships to spatial working memory. J Cogn Neurosci. 2002;14:508–23.

    Article  PubMed  Google Scholar 

  35. Corbetta M, Shulman GL. Control of goal-directed and stimulus-driven attention in the brain. Nat Rev Neurosci. 2002;3:201–15.

    Article  PubMed  CAS  Google Scholar 

  36. Kinsbourne M. A model for the mechanism of unilateral neglect of space. Trans Am Neurol Assoc. 1970;95:143–6.

    PubMed  CAS  Google Scholar 

  37. Kinsbourne M. Orienting bias model of unilateral neglect: Evidence from attentional gradients within hemispace. In: Robertson IH, Marshall JC, editors. Unilateral neglect: clinical and experimental studies. Hove: Lawrence Erlbaum; 1993. p. 63–86.

    Google Scholar 

  38. Posner MI, Walker JA, Friedrich FA, Rafal RD. Effects of parietal injury on covert orienting of attention. J Neurosci. 1984;4:1863–74.

    PubMed  CAS  Google Scholar 

  39. Posner MI, Walker JA, Friedrich FA, Rafal RD. How do the parietal lobes direct covert attention? Neuropsychologia. 1987;25:135–45.

    Article  PubMed  CAS  Google Scholar 

  40. Levy J, Heller W, Banich MT, Burton LA. Asymmetry of perception in free viewing of chimaeric faces. Brain Cogn. 1983;2:404–19.

    Article  PubMed  CAS  Google Scholar 

  41. Heller W, Levy J. Perception and expression of emotion in right-handers and left-handers. Neuropsychologia. 1981;19:263–72.

    Article  PubMed  CAS  Google Scholar 

  42. Demaree HA, Everhart DE, Youngstrom EA, Harrison DW. Brain lateralization of emotional processing: historical roots and a future incorporating “dominance”. Behav Cogn Neurosci Rev. 2005;4:3–20.

    Article  PubMed  Google Scholar 

  43. Mattingley JB, Bradshaw JL, Nettleton NC, Bradshaw JA. Can task specific perceptual bias be distinguished from unilateral neglect? Neuropsychologia. 1994;32:805–17.

    Article  PubMed  CAS  Google Scholar 

  44. Dehaene S. The neural basis of the Weber–Fechner law: a logarithmic mental number line. Trends Cogn Sci. 2003;7:145–7.

    Article  PubMed  Google Scholar 

  45. Umiltà C, Priftis K, Zorzi M. The spatial representation of numbers: evidence from neglect and pseudoneglect. Exp Brain Res. 2009;192:561–9.

    Article  PubMed  Google Scholar 

  46. Zorzi M, Priftis K, Meneghello F, Marenzi R, Umiltà C. The spatial representation of numerical and non-numerical sequences: evidence from neglect. Neuropsychologia. 2006;44:1061–7.

    Article  PubMed  Google Scholar 

  47. Zorzi M, Priftis K, Umiltà C. Brain damage: neglect disrupts the mental number line. Nature. 2002;417:138–9.

    Article  PubMed  CAS  Google Scholar 

  48. Behrmann M, Ghiselli-Crippa T, Sweeney JA, Di Matteo I, Kass R. Mechanisms underlying spatial representation revealed through studies of hemispatial neglect. J Cogn Neurosci. 2002;14:272–90.

    Article  PubMed  Google Scholar 

  49. De Renzi E, Gentilini M, Faglioni P, Barbieri C. Attentional shift towards the rightmost stimuli in patients with left visual neglect. Cortex. 1989;25:231–7.

    Article  PubMed  Google Scholar 

  50. Natale E, Marzi CA, Bricolo E, Johannsen L, Karnath HO. Abnormally speeded saccades to ipsilesional targets in patients with spatial neglect. Neuropsychologia. 2007;45:263–72.

    Article  PubMed  CAS  Google Scholar 

  51. Behrmann M, Watt S, Black SE, Barton JJ. Impaired visual search in patients with unilateral neglect: an oculographic analysis. Neuropsychologia. 1997;35:1445–58.

    Article  PubMed  CAS  Google Scholar 

  52. Bartolomeo P, Chokron S. Orienting of attention in left unilateral neglect. Neurosci Biobehav Rev. 2002;26:217–34.

    Article  PubMed  Google Scholar 

  53. Losier BJ, Klein RM. A review of the evidence for a disengage deficit following parietal lobe damage. Neurosci Biobehav Rev. 2001;25:1–13.

    Article  PubMed  CAS  Google Scholar 

  54. Robertson IH, Manly T, Beschin N, Daini R, Haeske-Dewick H, Hömberg V, et al. Auditory sustained attention is a marker of unilateral spatial neglect. Neuropsychologia. 1997;35:1527–32.

    Article  PubMed  CAS  Google Scholar 

  55. Robertson IH, Tegnér R, Tham K, Lo A, Nimmo-Smith I. Sustained attention training for unilateral neglect: theoretical and rehabilitation implications. J Clin Exp Neuropsychol. 1995;17:416–30.

    Article  PubMed  CAS  Google Scholar 

  56. Robertson IH, Ward A, Ridgeway V, Nimmo-Smith I. Test of everyday attention. Flempton: Thames Valley Test Company; 1994.

    Google Scholar 

  57. Robertson IH, Ward T, Ridgeway V, Nimmo-Smith I. The structure of normal human attention: the Test of Everyday Attention. J Int Neuropsychol Soc. 1996;2:525–34.

    Article  PubMed  CAS  Google Scholar 

  58. Husain M, Nachev P. Space and the parietal cortex. Trends Cogn Sci. 2007;11:30–6.

    Article  PubMed  Google Scholar 

  59. Husain M, Rorden C. Non-spatially lateralised mechanisms in hemispatial neglect. Nat Rev Neurosci. 2003;4:26–36.

    Article  PubMed  CAS  Google Scholar 

  60. Robertson IH. Do we need the “lateral” in unilateral neglect? Spatially non-selective attention deficits in unilateral neglect and their implications for rehabilitation. Neuroimage. 2001;14:S85–90.

    Article  PubMed  CAS  Google Scholar 

  61. Robertson IH, Mattingley JB, Rorden C, Driver J. Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness. Nature. 1998;395:169–72.

    Article  PubMed  CAS  Google Scholar 

  62. Husain M, Shapiro K, Martin J, Kennard C. Abnormal temporal dynamics of visual attention in spatial neglect patients. Nature. 1997;385:154–6.

    Article  PubMed  CAS  Google Scholar 

  63. Chun MM, Potter MC. A two-stage model for multiple target detection in rapid serial visual presentation. J Exp Psychol Hum Percept Perform. 1995;21:109–27.

    Article  PubMed  CAS  Google Scholar 

  64. Raymond JE, Shapiro KL, Arnell KM. Temporary suppression of visual processing in an RSVP task: an attentional blink? J Exp Psychol Hum Percept Perform. 1992;18:849–60.

    Article  PubMed  CAS  Google Scholar 

  65. Livesey EJ, Harris IM. Target sparing effects in the attentional blink depend on type of stimulus. Atten Percept Psychophys. 2011;73:2104–23.

    Article  PubMed  Google Scholar 

  66. Shapiro K, Hillstrom AP, Husain M. Control of visuotemporal attention by inferior parietal and superior temporal cortex. Curr Biol. 2002;12:1320–5.

    Article  PubMed  CAS  Google Scholar 

  67. Rizzo M, Akutsu H, Dawson J. Increased attentional blink after focal cerebral lesions. Neurology. 2001;57:795–800.

    Article  PubMed  CAS  Google Scholar 

  68. Schweizer TA, Alexander MP, Cusimano M, Stuss DT. Fast and efficient visuotemporal attention requires the cerebellum. Neuropsychologia. 2007;45:3068–74.

    Article  PubMed  Google Scholar 

  69. Ferber S, Danckert J. Lost in space—the fate of memory representations for non-neglected stimuli. Neuropsychologia. 2006;44:320–5.

    Article  PubMed  Google Scholar 

  70. Wojciulik E, Husain M, Clarke K, Driver J. Spatial working memory deficit in unilateral neglect. Neuropsychologia. 2001;39:390–6.

    Article  PubMed  CAS  Google Scholar 

  71. Wojciulik E, Rorden C, Clarke K, Husain M, Driver J. Group study of an “undercover” test for visuospatial neglect: invisible cancellation can reveal more neglect than standard cancellation. J Neurol Neurosurg Psychiatry. 2004;75:1356–8.

    Article  PubMed  CAS  Google Scholar 

  72. Parton A, Malhotra P, Nachev P, Ames D, Ball J, Chataway J, et al. Space re-exploration in hemispatial neglect. Neuroreport. 2006;17:833–6.

    Article  PubMed  Google Scholar 

  73. Malhotra P, Mannan S, Driver J, Husain M. Impaired spatial working memory: one component of the visual neglect syndrome? Cortex. 2004;40:667–76.

    Article  PubMed  Google Scholar 

  74. Basso G, Nichelli P, Frassinetti F, di Pellegrino G. Time perception in a neglected space. Neuroreport. 1996;7:2111–4.

    Article  PubMed  CAS  Google Scholar 

  75. Danckert J, Ferber S, Pun C, Broderick C, Striemer C, Rock S, et al. Neglected time: impaired temporal perception of multisecond intervals in unilateral neglect. J Cogn Neurosci. 2007;19:1706–20.

    Article  PubMed  Google Scholar 

  76. Merrifield C, Hurwitz M, Danckert J. Multimodal temporal perception deficits in a patient with left spatial neglect. Cogn Neurosci. 2010;4:244–53.

    Google Scholar 

  77. Becchio C, Bertone C. Time and neglect: abnormal temporal dynamics in unilateral spatial neglect. Neuropsychologia. 2006;44:2775–82.

    Article  PubMed  Google Scholar 

  78. Harrington DL, Haaland KY, Knight RT. Cortical networks underlying mechanisms of time perception. J Neurosci. 1998;18:1085–95.

    PubMed  CAS  Google Scholar 

  79. Aboulafia-Brakha T, Christe B, Martory MD, Annoni JM. Theory of mind tasks and executive functions: a systematic review of group studies in neurology. J Neuropsychol. 2011;5:39–55.

    Article  PubMed  CAS  Google Scholar 

  80. Danckert J, Ferber S, Doherty T, Steinmetz H, Nicolle D, Goodale MA. Selective, non-lateralized impairment of motor imagery following right parietal damage. Neurocase. 2002;8:194–204.

    PubMed  Google Scholar 

  81. Sirigu A, Duhamel J, Cohen L, Pillon B, Dubois B, Agid Y. The mental representation of hand movements after parietal cortex damage. Science. 1996;273(5281):1564–8.

    Article  PubMed  CAS  Google Scholar 

  82. Wolpert DM, Miall RC, Kawato M. Internal models in the cerebellum. Trends Cogn Sci. 1998;2:338–47.

    Article  PubMed  CAS  Google Scholar 

  83. Wolpert DM, Goodbody SJ, Husain M. Maintaining internal representations: the role of the human superior parietal lobe. Nat Neurosci. 1998;1:529–33.

    Article  PubMed  CAS  Google Scholar 

  84. Tenenbaum JB, Kemp C, Griffiths TL, Goodman ND. How to grow a mind: statistics, structure, and abstraction. Science. 2011;331:1279–85.

    Article  PubMed  CAS  Google Scholar 

  85. Pisella L, Mattingley JB. The contribution of spatial remapping to unilateral visual neglect. Neurosci Biobehav Rev. 2004;28:181–200.

    Article  PubMed  Google Scholar 

  86. Duhamel JR, Goldberg ME, Fitzgibbon EJ, Sirigu A, Grafman J. Saccadic dysmetria in a patient with a right fronto-parietal lesion: the importance of corollary discharge for accurate spatial behaviour. Brain. 1992;115:1387–402.

    Article  PubMed  Google Scholar 

  87. Heide W, Blankenburg M, Zimmermann E, Kömpf D. Cortical control of double-step saccades: implications for spatial orientation. Ann Neurol. 1995;38:739–48.

    Article  PubMed  CAS  Google Scholar 

  88. Striemer C, Danckert J. Through a prism darkly: re-evaluating prisms and neglect. Trends Cogn Sci. 2010;14:308–16.

    Article  PubMed  Google Scholar 

  89. Striemer C, Danckert J. Dissociating perceptual and motor effects of prism adaptation in spatial neglect. Neuroreport. 2010;21:436–41.

    Article  PubMed  Google Scholar 

  90. Druker M, Anderson B. Spatial probability AIDS visual stimulus discrimination. Front Hum Neurosci. 2010;4:63.

    PubMed  Google Scholar 

  91. Craik K. The nature of explanation. New York: Cambridge University Press; 1943.

    Google Scholar 

  92. Johnson-Laird PN. Mental models and human reasoning. Proc Natl Acad Sci USA. 2010;107:18243–50.

    Article  PubMed  CAS  Google Scholar 

  93. Blakemore SJ, Goodbody SJ, Wolpert DM. Predicting the consequences of our own actions: the role of sensorimotor context estimation. J Neurosci. 1998;18:7511–8.

    PubMed  CAS  Google Scholar 

  94. Desmurget M, Epstein CM, Turner RS, Prablanc C, Alexander GE, Grafton ST. Role of the posterior parietal cortex in updating reaching movements to a visual target. Nat Neurosci. 1999;2:563–7.

    Article  PubMed  CAS  Google Scholar 

  95. Frith CD, Blakemore SJ, Wolpert DM. Abnormalities in the awareness and control of action. Philos Trans R Soc Lond B Biol Sci. 2000;355:1771–88.

    Article  PubMed  CAS  Google Scholar 

  96. Danckert J, Stöttinger E, Quehl N, Anderson B. Right hemisphere brain damage impairs strategy updating. Cereb Cortex. 2012;22(12):2745–60. Epub 2011 Dec 15.

    Article  PubMed  Google Scholar 

  97. Vallar G, Perani D. The anatomy of unilateral neglect after right hemisphere stroke lesions. A clinical/CT-scan correlation study in man. Neuropsychologia. 1986;24:609–22.

    Article  PubMed  CAS  Google Scholar 

  98. Karnath HO, Ferber S, Himmelbach M. Spatial awareness is a function of the temporal not the posterior parietal lobe. Nature. 2001;411:950–3.

    Article  PubMed  CAS  Google Scholar 

  99. Mort DJ, Malhotra P, Mannan SK, Rorden C, Pambakian A, Kennard C, et al. The anatomy of visual neglect. Brain. 2003;126:1986–97.

    Article  PubMed  Google Scholar 

  100. Ferber S, Karnath HO. How to assess spatial neglect—line bisection or cancellation tasks? J Clin Exp Neuropsychol. 2001;23:599–607.

    Article  PubMed  CAS  Google Scholar 

  101. Buxbaum LJ, Ferraro MK, Veramonti T, Farne A, Whyte J, Ladavas E, et al. Hemispatial neglect: subtypes, neuroanatomy, and disability. Neurology. 2004;62:749–56.

    Article  PubMed  CAS  Google Scholar 

  102. Chechlacz M, Rotshtein P, Bickerton WL, Hansen PC, Deb S, Humphreys GW. Separating neural correlates of allocentric and egocentric neglect: distinct cortical sites and common white matter disconnections. Cogn Neuropsychol. 2010;27:277–303.

    Article  PubMed  Google Scholar 

  103. Rorden C, Fruhmann Berger M, Karnath HO. Disturbed line bisection is associated with posterior brain lesions. Brain Res. 2006;1080:17–25.

    Article  PubMed  CAS  Google Scholar 

  104. Verdon V, Schwartz S, Lovblad KO, Hauert CA, Vuilleumier P. Neuroanatomy of hemispatial neglect and its functional components: a study using voxel-based lesion-symptom mapping. Brain. 2010;133:880–94.

    Article  PubMed  Google Scholar 

  105. Bartolomeo P, Thiebaut de Schotten M, Doricchi F. Left unilateral neglect as a disconnection syndrome. Cereb Cortex. 2007;17:2479–90.

    Article  PubMed  Google Scholar 

  106. Doricchi F, Thiebaut de Schotten M, Tomaiuolo F, Bartolomeo P. White matter (dis)connections and gray matter (dys)functions in visual neglect: gaining insights into the brain networks of spatial awareness. Cortex. 2008;44:983–95.

    Article  PubMed  Google Scholar 

  107. Bird CM, Malhotra P, Parton A, Coulthard E, Rushworth MF, Husain M. Visual neglect following right posterior cerebral artery infarction. J Neurol Neurosurg Psychiatry. 2006;77:1008–12.

    Article  PubMed  CAS  Google Scholar 

  108. Doricchi F, Tomaiuolo F. The anatomy of neglect without hemianopia: a key role for parietal-frontal disconnection? Neuroreport. 2003;14:2239–43.

    Article  PubMed  Google Scholar 

  109. Thiebaut de Schotten M, Urbanski M, Duffau H, Volle E, Lévy R, Dubois B, et al. Direct evidence for a parietal frontal pathway subserving spatial awareness in humans. Science. 2005;309:2226–8.

    Article  PubMed  CAS  Google Scholar 

  110. Urbanski M, Thiebaut de Schotten M, Rodrigo S, Oppenheim C, Touzé E, Méder JF, et al. DTI-MR tractography of white matter damage in stroke patients with neglect. Exp Brain Res. 2011;208:491–505.

    Article  PubMed  CAS  Google Scholar 

  111. Urbanski M, Thiebaut de Schotten M, Rodrigo S, Catani M, Oppenheim C, Touzé E, et al. Brain networks of spatial awareness: evidence from diffusion tensor imaging tractography. J Neurol Neurosurg Psychiatry. 2008;79:598–601.

    Article  PubMed  CAS  Google Scholar 

  112. Farné A, Buxbaum LJ, Ferraro M, Frassinetti F, Whyte J, Veramonti T, et al. Patterns of spontaneous recovery of neglect and associated disorders in acute right brain-damaged patients. J Neurol Neurosurg Psychiatry. 2004;75:1401–10.

    Article  PubMed  Google Scholar 

  113. Adair JC, Na DL, Schwartz RL, Heilman KM. Caloric stimulation in neglect: evaluation of response as a function of neglect type. J Int Neuropsychol Soc. 2003;9:983–8.

    Article  PubMed  Google Scholar 

  114. Karnath HO, Christ K, Hartje W. Decrease of contralateral neglect by neck muscle vibration and spatial orientation of trunk midline. Brain. 1993;116:383–96.

    Article  PubMed  Google Scholar 

  115. Karnath HO, Fetter M, Dichgans J. Ocular exploration of space as a function of neck proprioceptive and vestibular input: observations in normal subjects and patients with spatial neglect after parietal lesions. Exp Brain Res. 1996;109:333–42.

    Article  PubMed  CAS  Google Scholar 

  116. Rubens AB. Caloric stimulation and unilateral visual neglect. Neurology. 1985;35:1019–24.

    Article  PubMed  CAS  Google Scholar 

  117. Eskes GA, Butler B, McDonald A, Harrison ER, Phillips SJ. Limb activation effects in hemispatial neglect. Arch Phys Med Rehabil. 2003;84:323–8.

    Article  PubMed  Google Scholar 

  118. Rossi PW, Kheyfets S, Reding MJ. Fresnel prisms improve visual perception in stroke patients with homonymous hemianopia or unilateral visual neglect. Neurology. 1990;40:1597–9.

    Article  PubMed  CAS  Google Scholar 

  119. Rossetti Y, Rode G, Pisella L, Farné A, Li L, Boisson D, Perenin MT. Prism adaptation to a rightward optical deviation rehabilitates left hemispatial neglect. Nature. 1998;395:166–9.

    Article  PubMed  CAS  Google Scholar 

  120. Nys GMS, de Haan EHF, Kunneman A, de Kort PL, Dijkerman HC. Acute neglect rehabilitation using repetitive prism adaptation. A randomized placebo-controlled trial. Restor Neurol Neurosci. 2008;26:1–12.

    PubMed  CAS  Google Scholar 

  121. Turton AJ, O’Leary K, Gabb J, Woodward R, Gilchrist ID. A single blinded randomised controlled pilot trial of prism adaptation for improving self-care in stroke patients with neglect. Neuropsychol Rehabil. 2010;20:180–96.

    Article  PubMed  Google Scholar 

  122. Redding GM, Wallace B. Prism adaptation and unilateral neglect: review and analysis. Neuropsychologia. 2006;44:1–20.

    Article  PubMed  Google Scholar 

  123. Pisella L, Rode G, Farné A, Tilikete C, Rossetti Y. Prism adaptation in the rehabilitation of patients with visuo-spatial cognitive disorders. Curr Opin Neurol. 2006;19:534–42.

    Article  PubMed  Google Scholar 

  124. Ferber S, Danckert J, Joanisse M, Goltz HC, Goodale MA. Eye movements tell only half the story. Neurology. 2003;60:1826–9.

    Article  PubMed  CAS  Google Scholar 

  125. Tilikete C, Rode G, Rossetti Y, Pichon J, Li L, Boisson D. Prism adaptation to rightward optical deviation improves postural imbalance in left-hemiparetic patients. Curr Biol. 2001;11:524–8.

    Article  PubMed  CAS  Google Scholar 

  126. Striemer C, Danckert J. Prism adaptation reduces the disengage deficit in right brain damage patients. Neuroreport. 2007;18:99–103.

    Article  PubMed  Google Scholar 

  127. Frassinetti F, Angelini V, Meneghello F, Avanzi S, Làdavas E. Long-lasting amelioration of visuospatial neglect by prism adaptation. Brain. 2002;125:608–23.

    Article  PubMed  Google Scholar 

  128. Striemer C, Sablatnig J, Danckert J. Differential influences of prism adaptation on reflexive and voluntary covert attention. J Int Neuropsychol Soc. 2006;12:337–49.

    Article  PubMed  Google Scholar 

  129. Nijboer TC, McIntosh RD, Nys GM, Dijkerman HC, Milner AD. Prism adaptation improves voluntary but not automatic orienting in neglect. Neuroreport. 2008;19:293–8.

    Article  PubMed  Google Scholar 

  130. Dijkerman HC, McIntosh RD, Milner AD, Rossetti Y, Tilikete C, Roberts RC. Ocular scanning and perceptual size distortion in hemineglect: effects of prism adaptation and sequential stimulus presentation. Exp Brain Res. 2003;153:220–30.

    Article  PubMed  Google Scholar 

  131. Goodale MA, Milner AD. Separate visual pathways for perception and action. Trends Neurosci. 1992;15:20–5.

    Article  PubMed  CAS  Google Scholar 

  132. Karnath HO, Fruhmann-Berger M, Küker W, Rorden C. The anatomy of spatial neglect based on voxelwise statistical analysis: a study of 140 patients. Cereb Cortex. 2004;14:1164–72.

    Article  PubMed  Google Scholar 

  133. Karnath HO, Rorden C, Ticini LF. Damage to white matter fiber tracts in acute spatial neglect. Cereb Cortex. 2009;19:2331–7.

    Article  PubMed  Google Scholar 

  134. Karnath HO, Rennig J, Johannsen L, Rorden C. The anatomy underlying acute versus chronic spatial neglect: a longitudinal study. Brain. 2011;134:903–12.

    Article  PubMed  Google Scholar 

  135. Ptak R, Schnider A. The attention network of the human brain: relating structural damage associated with spatial neglect to functional imaging correlates of spatial attention. Neuropsychologia. 2011;49:3063–70.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychology, University of Waterloo, 200 University Avenue West, Waterloo, ON, Canada, N2L 3G1

    James Danckert Ph.D.

Authors
  1. James Danckert Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to James Danckert Ph.D. .

Editor information

Editors and Affiliations

  1. University of Toronto Division of Neurosurgery, St. Michael’s Hospital Neuroscience Research Program, Toronto, Ontario, Canada

    Tom A. Schweizer

  2. University of Toronto Department of Surgery, St. Michael’s Hospital Division of Neurosurgery, Toronto, Ontario, Canada

    R. Loch Macdonald

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Danckert, J. (2014). Spatial Neglect: Not Simply Disordered Attention. In: Schweizer, T., Macdonald, R. (eds) The Behavioral Consequences of Stroke. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7672-6_5

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-7672-6_5

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7671-9

  • Online ISBN: 978-1-4614-7672-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation