Human Sleep-Disordered Breathing

  • Clifford W. Zwillich
  • Laurel Wiegand
  • Kevin Gleeson
  • John L. Stauffer
  • David P. White
Part of the Clinical Physiology book series (CLINPHY)


obstructive sleep apnea is a common clinical disorder primarily affecting men who have a long history of heavy snoring. The incidence of the illness increases with both aging and obesity; its major clinical manifestation is the complaint of daytime hypersomnolence. This illness has received a great deal of clinical and investigative attention in the last ten years because its occurrence appears almost epidemic in nature. In addition, apnea-associated cardiac rhythm abnormalities raise the question of the possible influence of obstructive sleep apnea on unexplained nocturnal death. Recently other associated cardiovascular abnormalities, such as sustained pulmonary and systemic hypertension, have resulted in further interest in this recently discovered illness.


Obstructive Sleep Apnea Sleep Apnea Carotid Body Breath Holding NREM Sleep 
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Copyright information

© American Physiological Society 1988

Authors and Affiliations

  • Clifford W. Zwillich
    • 1
  • Laurel Wiegand
    • 1
  • Kevin Gleeson
    • 1
  • John L. Stauffer
    • 1
  • David P. White
    • 1
  1. 1.Pulmonary DivisionMilton S. Hershey Medical Center of the Pennsylvania State UniversityHersheyUSA

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