Abstract
obstructive sleep apnea is a common clinical disorder primarily affecting men who have a long history of heavy snoring. The incidence of the illness increases with both aging and obesity; its major clinical manifestation is the complaint of daytime hypersomnolence. This illness has received a great deal of clinical and investigative attention in the last ten years because its occurrence appears almost epidemic in nature. In addition, apnea-associated cardiac rhythm abnormalities raise the question of the possible influence of obstructive sleep apnea on unexplained nocturnal death. Recently other associated cardiovascular abnormalities, such as sustained pulmonary and systemic hypertension, have resulted in further interest in this recently discovered illness.
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References
Bradley, T. D., I. G. Brown, R. F. Grossman, N. Zamel, D. Martinez, E. A. Phillipson, And V. Hoffstein. Pharyngeal size in snorers, nonsnorers, and patients with obstructive sleep apnea. N. Engl. J. Med. 315: 1327–1331, 1986.
Brown, I. G., T. D. Bradley, E. A. Phillipson, N. Zamel, And V. Hoffstein. Pharyngeal compliance in snoring subjects with and without obstructive sleep apnea. Am. Rev. Respir. Dis. 132: 211–215, 1985.
Burwell, C. S., E. D. Robin, And R. D. Whaley. Extreme obesity associated with alveolar hypoventilation: a Pickwickian syndrome. Am. J. Med. 21: 811–818, 1956.
Deburgh Daly, M., And M. J. Scott. The effects of stimulation of the carotid body chemoreceptors on heart rate in the dog. J. Physiol. Lond. 144: 148–166, 1958.
Dickens, C. The Posthumous Papers of the Pickwickian Club. London: Chapman & Hall, 1837.
Gastaut, H., C. A. Tassinari, And B. Daron. Polygraphic study of the episodic diurnal and nocturnal hypneic and respiratory manifestations of the Pickwick syndrome. Brain Res. 2: 167–186, 1966.
Gleeson, K., C. W. Zwillich, And D. P. White. Progressively increasing resistive loads do not reduce ventilation during sleep (Abstract). Am. Rev. Respir. Dis. 133, Suppl.: A308, 1986.
Guilleminault, C., S. Connolly, R. Winkle, K. Melvin, And A. Tilkian. Cyclical variation of the heart rate in sleep apnoea syndrome. Lancet 1: 126–131, 1984.
Haponik, E., P. Smith, M. Bohlman, And R. P. Allen Computerized tomography in obstructive sleep apnea: correlation of airway size with physiology during sleep and wakefulness. Am. Rev. Respir. Dis. 127: 221–226, 1983.
Iber, C., A. Berssengrugge, J. Skatrud, And J. Dempsey. Ventilatory adaptation to resistive loading during wakefulness and non-Rem sleep. J. Appl. Physiol. 52: 607–614, 1982.
Martin, R. J., M. H. Sanders, B. A. Gray, And B. E. Pennock. Acute and long-term ventilatory effects of hyperoxia in the adult sleep apnea syndrome. Am. Rev. Respir. Dis. 125: 175–180, 1982.
Motta, J., C. Guilleminault, J. S. Schroeder, And W. C. Dement. Tracheostomy and hemodynamic changes in sleep-induced apnea. Ann. Intern. Med. 89: 454–458, 1978.
Remmers, J. E., W. J. Degroot, E. K. Sauerland, And A. M. Anch. Pathogenesis of upper airway occlusion during sleep. J. Appl. Physiol. 44: 931–938, 1978.
Santiago, T., C. Remolina, V. Scoles, And N. Edelman. Endorphins and the control of breathing. N. Engl. J. Med. 304: 1190–1195, 1981.
Sauerland, E. K., W. C. Orr, And L. E. Hairston. Emg patterns of oropharyngeal muscles during respiration during wakefulness and sleep. Electromyogr. Clin. Neurophysiol. 21: 307–316, 1981.
Scholander, P. F., H. T. Hammel, E. Lemessurier, E. Hemmingsen, And W. Garly. Circulatory adjustment in pearl divers. J. Appl. Physiol. 17: 184–149, 1962.
Skatrud, J., And J. A. Dempsey. Airway resistance and respiratory muscle function in snorers during Nrem sleep. J. Appl. Physiol. 59: 328–335, 1985.
Stauffer, J. L., R. Cadiuex, E. O. Bixler, A. Kales, L. Varrano, And D. P. White. Pharyngeal size and resistance in obstructive sleep apnea. Am. Rev. Respir. Dis. 136: 623627, 1987.
Surarr, P. M., R. F. Metier, And S. C. Wilhoit. Collapsibility of the nasopharyngeal airway in obstructive sleep apnea. Am. Rev. Respir. Dis. 132: 967–971, 1985.
Tilkian, A. J., J. Motta, And C. Guilleminault. In: Sleep Apnea Syndromes, edited by C. Guilleminault and W. Dement. New York: Liss, 1978, p. 197–210.
White, D. P., R. M. Lombard, R. J. Cadieux, And C. W. Zwillich. Pharyngeal resistance in normal humans: influence of gender, age, and obesity. J. Appl. Physiol. 58: 365371, 1985.
Wiegand, L., C. W. Zwillich, And D. P. White. The influence of sleep on the ventilatory response to inspiratory flow-resistive loading (Abstract). Am. Rev. Respir. Dis. 135: A182, 1987.
Wiegand, L., C. W. Zwillich, And D. P. White. Sleep and the ventilatory response to resistive loading in normal men. J. Appl. Physiol. 64: 1186–1195, 1988.
Zwillich, C. W., T. Devlin, D. P. White, N. J. Douglas, J. V. Weil, And R. J. Martin. Bradycardia during sleep apnea: its characteristics and mechanisms. J. Clin. Invest. 69: 1286–1292, 1982.
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© 1988 American Physiological Society
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Zwillich, C.W., Wiegand, L., Gleeson, K., Stauffer, J.L., White, D.P. (1988). Human Sleep-Disordered Breathing. In: Lydic, R., Biebuyck, J.F. (eds) Clinical Physiology of Sleep. Clinical Physiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7599-6_8
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DOI: https://doi.org/10.1007/978-1-4614-7599-6_8
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