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Anesthesia and Sleep: A Search for Mechanisms and Research Approaches

  • Julien F. Biebuyck
Part of the Clinical Physiology book series (CLINPHY)

Abstract

traditional and recent approaches to research addressing the possible mechanisms of deliberate altered consciousness produced by exogenous agents (anesthesia) have included particularly research by neurophysiologists, neurochemists, physical chemists, and more recently biophysicists. At least two Nobel Prize winners have directed their attention to possible mechanisms of action of anesthetic agents (3, 16, 25). Many intellectual leaders in various fields of science have questioned the nature and interrelationship of the sleep, the anesthetic, the comatose, and the awake states. For a time, some fifty to seventy-five years ago, drug-induced altered consciousness was actually considered to be related to an interference with the supply and utilization of oxygen at the cellular level in the brain (27, 30).

Keywords

Nicotinic Acetylcholine Receptor Oxygen Desaturation Conscious State Nobel Prize Winner Clinical Physiology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© American Physiological Society 1988

Authors and Affiliations

  • Julien F. Biebuyck
    • 1
  1. 1.Department of AnesthesiaThe Pennsylvania State University College of MedicineHersheyUSA

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