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Clinical Physiology of Sleep pp 221–228Cite as

Anesthesia and Sleep: A Search for Mechanisms and Research Approaches

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Abstract

traditional and recent approaches to research addressing the possible mechanisms of deliberate altered consciousness produced by exogenous agents (anesthesia) have included particularly research by neurophysiologists, neurochemists, physical chemists, and more recently biophysicists. At least two Nobel Prize winners have directed their attention to possible mechanisms of action of anesthetic agents (3, 16, 25). Many intellectual leaders in various fields of science have questioned the nature and interrelationship of the sleep, the anesthetic, the comatose, and the awake states. For a time, some fifty to seventy-five years ago, drug-induced altered consciousness was actually considered to be related to an interference with the supply and utilization of oxygen at the cellular level in the brain (27, 30).

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Author information

Authors and Affiliations

  1. Department of Anesthesia, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

    Julien F. Biebuyck

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  1. Julien F. Biebuyck
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Editors and Affiliations

  1. Departments of Medicine and Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

    Ralph Lydic

  2. Department of Anesthesia, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA

    Julien F. Biebuyck

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© 1988 American Physiological Society

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Biebuyck, J.F. (1988). Anesthesia and Sleep: A Search for Mechanisms and Research Approaches. In: Lydic, R., Biebuyck, J.F. (eds) Clinical Physiology of Sleep. Clinical Physiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7599-6_15

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  • DOI: https://doi.org/10.1007/978-1-4614-7599-6_15

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7599-6

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