Oxygen Biology of Peripheral Chemoreceptors

  • Sukhamay Lahiri
Part of the Clinical Physiology Series book series (CLINPHY)


The focus of this chapter is on “adaptive” response of aortic and carotid body chemoreceptors to chronic hyperoxia, which generates an overwhelming excess of oxygen-related free radicals (13). Prolonged normobaric hyperoxia would allow the organism to develop responses and adaptation that may not be expressed during acute hyperbaric hyperoxia. This chapter deals with two aspects of chemoreceptive functions. First, the hypothesis that aortic chemoreceptor responses to chronic hyperoxia would be different from those of carotid chemoreceptors because of a possible difference in oxygen flow to the two chemoreceptor organs (18). If proven, the results would further add to the evidence that aortic body chemoreceptors monitor combined state of systemic circulatory and respiratory oxygen flow and carotid body chemoreceptors monitor respiratory oxygen flow (18, 22). Accordingly, the two chemoreflexes from the two chemoreceptor organs are designed to perform two separate but complementary functions related to oxygen transport to tissues. The second aspect concerns the mechanism of adaptive response of peripheral chemoreceptors to chronic hyperoxia.


Carotid Body Glomus Cell Peripheral Chemoreceptor Erythropoietin Production Chemosensory Response 
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© American Physiological Society 1991

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  • Sukhamay Lahiri

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