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Renal Physiology pp 131–163Cite as

From Renal Tissue Slices to Membrane Vesicles

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Abstract

This chapter appraises the development of investigative approaches for the dissection of renal function at the cellular level by experimentation in vitro. Such analysis cannot be separated from the nature of the questions asked and reflects the imagination of the investigators involved. The basic criterion for this evaluation has been set by Otto Warburg et al. [(113); translated by me from the German]:

There can be no argument about the unconditional priority of experiments in vivo. If manometric [e.g., in vitro] and in vivo experimentation are consistent, this offers the possibility of carrying out studies under simplified conditions. If, however, there is no consistence1, then experiments in vitro are biologically worthless.

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Authors
  1. Arnost Kleinzeller
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Editor information

Editors and Affiliations

  1. American Heart Association, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Carl W. Gottschalk (Career Investigator, Kenan Professor of Medicine and Physiology) (Career Investigator, Kenan Professor of Medicine and Physiology)

  2. Yale University School of Medicine, New Haven, Connecticut, USA

    Robert W. Berliner (Professor Emeritus of Physiology and Medicine) (Professor Emeritus of Physiology and Medicine)

  3. Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA

    Gerhard H. Giebisch (Sterling Professor of Physiology) (Sterling Professor of Physiology)

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© 1987 American Physiological Society

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Kleinzeller, A. (1987). From Renal Tissue Slices to Membrane Vesicles. In: Gottschalk, C.W., Berliner, R.W., Giebisch, G.H. (eds) Renal Physiology. People and Ideas. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7545-3_5

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  • DOI: https://doi.org/10.1007/978-1-4614-7545-3_5

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-7545-3

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