Pulmonary Hypoplasia: Role of Mechanical Factors in Prenatal Lung Growth

  • Richard Harding
  • Cheryl Albuquerque
Part of the Clinical Physiology Series book series (CLINPHY)


Pulmonary hypoplasia is a term used to describe lungs that are sufficiently restricted in growth such that their ability to exchange respiratory gases is impaired; however, hypoplastic lungs are usually not simply small but are also structurally abnormal or immature. It is now recognized that fetal lung hypoplasia rarely occurs in isolation and is usually associated with other intrauterine abnormalities. This chapter considers how such abnormalities result in lung hypoplasia, and how lung structure and function are affected. For further information, the reader is directed to reviews of lung hypoplasia and the control of fetal lung growth (34, 42, 48, 62, 78, 90, 96, 139, 149, 163, 168).


Fetal Lung Lung Development Congenital Diaphragmatic Hernia Pulmonary Hypoplasia Lung Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© American Physiological Society 1999

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  • Richard Harding
  • Cheryl Albuquerque

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