Hearts and Capillaries

  • John Henderson
Part of the People and Ideas Series book series (PEOPL)


During Queen Victoria’s reign, the British Raj provided employment for a marvellously wide range of expatriates. Among them was a barrister, Matthew Henry Starling, who was called to the bar in London in 1863, went to India in 1868, and spent the rest of his legal career in Bombay. There he served first as an advocate, and in 1887 was made clerk to the crown court for the rest of his life. On two occasions he was acting (“puisne”) high court judge (in 1895 and 1902) and wrote a standard textbook, Indian Criminal Law and Procedure, in 1869, which ran to five editions. It seems curious that a man with such a grasp of Indian law should only have been a locum, a standby, judge. He also seemed to be a stand-by husband; for in 1864 he married Ellen Matilda Watkins, of Islington, and left for India four years later, leaving her in Islington. His post allowed him ajourney home every three years, but his absence didn’t stop this enterprising couple from producing seven children over eleven years; six of the children were born in Islington and one in Bombay. How often did Ellen sail to India? We are unlikely to discover, but Theodora (born in 1865), Ernest Henry (1866), Gertrude (1867), Bernard (1869), Mabel (1872), Hubert (1874), and Bertha (1876) bore witness to the success of their parents’ social arrangements.


Capillary Pressure Inferior Vena Thoracic Duct Lymph Flow Electrical Wave 
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  1. Anonymous: In an unsigned obituary of Bayliss (it was actually written by Starling) in The Times, Aug 28, 1924, we read: “Here in the two rooms [in St. Cuthbert’s] assigned to him as a sanctum, one of which served as a laboratory, while the other, lined with books and with a little red lamp constantly burning in front of a picture of the Virgin and Child, provided him with a study …” If Bayliss had been a practicing Catholic, he was an unusual one, for he was a great admirer of Marie Stopes and her advocacy of birth control (see Chapter 5).Google Scholar
  2. Barcroft H. 1976. The Bayliss-Starling memorial lecture 1976: Lymph formation by secretion or filtration? J Physiol 260:1–20.PubMedGoogle Scholar
  3. Barcroft J. 1928. The entry for “Starling” in: Dictionary of National Biography. London: Oxford University Press, 1922-30, pp. 807–809.Google Scholar
  4. Bayliss L. 1960. The details of Bayliss’s life come mainly from his son, Leonard (Perspectives in Biology and Medicine, 4, 460–478).Google Scholar
  5. Bayliss WM, Starling EH. 1892a. On the electromotive phenomena of the mammalian heart. International Monatsschrift f Anat Physiol 9:256–281.Google Scholar
  6. -. 1892b. On some points in the innervation of the mammalian heart. J Physiol 13:407–418.PubMedGoogle Scholar
  7. -. 1894. Observations on venous pressures and their relationship to capillary pressures, J Physiol 16:159–202.PubMedGoogle Scholar
  8. Chapman CB. 1962. Ernest Henry Starling—the physician’s physiologist. Ann Int Med 57 part 2, suppl 2: 1–43.Google Scholar
  9. Frank RG. The tell-tale heart: physiological instruments, graphic methods and clinical hopes, 1854-1914. This outstanding account is in The Investigative Enterprise, Eds. Coleman W and Holmes FL. Berkeley: University of California Press, 1988, pp. 230–245.Google Scholar
  10. Heidenhain R. 1891. Versuche und fragen zur lehre von der lymphbilding. Pflügers Archives, Bd XLIX.Google Scholar
  11. Kedem O, Katchalsky A. 1958. Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochem Biophys Acta 27:229–246. In Kedem and Katchalsky’s formulation of Starling’s Principle, \( Jv/A = Lp\left\{ {\left[ {P_c - P_i } \right] - \sigma \left[ {\pi _p - \pi _i } \right]} \right\}, \) Jv/A is filtration rate per unit capillary area; Lp is wall conductance, Pc and Pi are the pressures of capillary blood and interstitial fluid respectively; πp and πi are the two osmotic pressures of plasma proteins in plasma and interstitial fluid respectively, a is the osmotic reflection co-efficient of the capillary wall to protein. It is always less than 1, because capillary walls are “leaky” to protein.PubMedCrossRefGoogle Scholar
  12. Levick JR. Exper Physiol 76:825–857, 1991; Phys Soc Mag 22:26-30, 1996. The modern applications of Starling’s Principle have been reviewed by Levick. He examined fourteen sets of experimental data where values of Pc, Pi, πp, and πi had been measured, and showed that net filtration pressure was always greater than absorption. The common view that, in an individual capillary, the two somehow balance, is clearly fallacious (except in renal capillaries, where absorption may dominate). Starling himself claimed a balance between filtration and absorption, but he was referring to overall values in the body, not values in individual capillaries. Starling proposed that the hydrostatic/ osmotic balance stabilized the circulating blood volume, as we saw in the description of his classic 1896 paper “On the absorption of fluid from the connective tissue spaces.”Google Scholar
  13. Martin CJ. 1927. Obituary “EH Starling.” British Medical Journal, 1:900–905. Martin knew Starling well, and this obituary is outstanding in its details of his research, but it says litde about his life.CrossRefGoogle Scholar
  14. Michel CC. 1977. Starling: the formulation of his hypothesis of micro-vascular fluid exchange and its significance after 100 years. Exper Physiol 82:1–30.Google Scholar
  15. Pye-Smith PH. 1889. Obituary notice of the late Leonard Charles Wooldridge. Guy’s Hosp Rep 46:35–42.Google Scholar
  16. Starling EH. 1892. These three letters from Starling are in the Special Collections library in University College London. They are unnumbered.Google Scholar
  17. -. Contribution to the physiology of lymph secretion. J Physiol 14:131–153, 1893. Starling’s tide(s) are given as “Joint Lecturer in Physiology at Guy’s Hospital and Grocers’ Research Scholar.” He supplemented his salary with support form the Grocers’ company in the City of London, following a year’s support from the British Medical Association. His address is given as “Physiological Institute, University of Breslau.”Google Scholar
  18. -. 1894a. The influence of mechanical factors on lymph production. J Physiol 16:224–267.PubMedGoogle Scholar
  19. -. 1894b. On the mode of action of lymphagogues. J Physiol 17:30–47.PubMedGoogle Scholar
  20. -. 1896. On the absorption of fluids from the connective tissue spaces. J Physiol, 19:312–326.PubMedGoogle Scholar
  21. -. Letter to Evans, 17 Jan 1919. In the Wellcome Library (CMAC:PP/CLE) Starling EH, 1890. Hopkins FG. Notes on the urine in a case of phosphorus poisoning. Guy’s Hosp Rep, 47:275–278.Google Scholar
  22. Starling EH, Tubby AH. On absorption and secretion into the serous cavities. J Physiol, 19:312–326, 1894. Tubby was a Guy’s graduate who became a lecturer in physiology there. Afterward he became an orthopaedic surgeon, though, curiously, he did not become a member of the Physiological Society until he had taken up his second career.Google Scholar
  23. Tawara S. Das Reizleitungssystem des Saugertierherzens, Jena: Gustav Fischer, 1906. Tawara’s name is not the only one associated with the conducting system of the heart. Others include Gaskell (1883), Kent (1893), and His (1893). Keith and Flack (Lancet ii Aug 11, 1906) provide a contemporary review.Google Scholar

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  • John Henderson

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