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Red Cell Function at Extreme Altitude

  • Robert M. Winslow
Part of the Clinical Physiology book series (CLINPHY)

Abstract

the relationship between the amount of oxygen bound to hemoglobin (saturation) and the oxygen physically dissolved in solution [oxygen tension (Po2)] under equilibrium conditions is the familiar oxygen equilibrium curve (OEC) of hemoglobin. Its position is often denoted by the value P50, the Po2 at which saturation is 50%. If oxygen affinity increases, the OEC shifts left and P50 is reduced. If oxygen affinity decreases, the OEC shifts right and P50 is increased. The principal effectors of hemoglobin function [Ht, 2,3-diphosphoglycerate (2,3-DPG), and carbon dioxide] all shift the OEC to the right.

Keywords

High Altitude Base Excess Oxygen Affinity Corpuscular Hemoglobin Concentration Arterial Saturation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© American Physiological Society 1984

Authors and Affiliations

  • Robert M. Winslow
    • 1
  1. 1.Division of Host Factors, Center for Infectious Diseases, Centers for Disease ControlPublic Health Services, United States Department of Health and Human ServicesAtlantaUSA

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