Cell-Mediated Interactions of Advanced Glycosylation End Products and the Vascular Wall

  • Helen Vlassara
Part of the Clinical Physiology Series book series (CLINPHY)


Thickening of the arterial wall in atherosclerosis is associated with abnormal basement membrane and subintimal collagen deposition, and the focal proliferation of vascular smooth muscle cells leads to an increase in peripheral resistance. Related events include increases in endothelial cell permeability and leakage, and the deposition of serum proteins, such as albumin, cholesterol esters, and fibrin. These pathological changes are believed to contribute to the pathogenesis of both the atherosclerotic and the thrombotic vasculopathies associated with aging and chronic diabetes (1,14,18,28).


Endothelial Cell Monolayer Radioreceptor Assay Tissue Factor Activity Advanced Glycosylation Glycation Product 
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© American Physiological Society 1992

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  • Helen Vlassara

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