Membrane Transport in Excitation-Contraction Coupling

  • Richard J. Podolsky
Part of the People and Ideas book series (PEOPL)


Excitation-contraction coupling is the sequence of largely membrane-dominated processes that follow depolarization of the outer membrane of a muscle cell and leads to activation of the contractile mechanism. The major steps in the sequence are listed in Figure 1. The definition of these events came about through the interaction of many investigators following many different lines of research [see reviews by Ebashi and Endo (6), Weber and Murray (36), Peachey and Franzini-Armstrong (27), Baylor (2), and Martonosi and Beeler (25)]. Several contributions to this story have come out of my laboratory, and this chapter describes how they came about.


Sarcoplasmic Reticulum Bathing Solution Contractile Response Intact Fiber Transverse Tubule 
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© American Physiological Society 1989

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  • Richard J. Podolsky

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