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Weakened All Weekend

Vecuronium, amikacin
  • Daniel W. Johnson

Abstract

This case discusses the complex pharmacodynamic interaction between vecuronium and amikacin resulting in increased neuromuscular blockade.

Keywords

Pharmacodynamic Vecuronium Amikacin 

References

  1. 1.
    Pino RM, Ali HH. Monitoring and Managing Neuromuscular Blockade. In: Longnecker DE, editor. Anesthesiology. New York: McGraw Hill Professional; 2008.Google Scholar
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    Naguib M, Lien C. Pharmacology of Muscle Relaxants and their Antagonists. In: Miller RD, editor. Miller’s anesthesia. 6th ed. Philadelphia: Elsevier Churchill Livingstone; 2005.Google Scholar
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    Shanks AB, Long T, Aitkenhead AR. Prolonged neuromuscular blockade following vecuronium. A case report. Br J Anaesth. 1985;57(8):807–10.PubMedCrossRefGoogle Scholar
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    Kronenfeld MA, Thomas SJ, Turndorf H. Recurrence of neuromuscular blockade after reversal of vecuronium in a patient receiving polymyxin/amikacin sternal irrigation. Anesthesiology. 1986;65(1):93–4.PubMedCrossRefGoogle Scholar
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    Singh YN, Marshall IG, Harvey AL. Pre- and postjunctional effects of aminoglycoside, polymyxin, tetracycline and lincosamide antibiotics. Br J Anaesth. 1982;54(12):1295–306.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Anesthesia, Critical Care and Pain MedicineMassachusetts General HospitalBostonUSA

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