CYP2E1: The Anesthesia Enzyme

  • Benjamin S. Gmelch
  • Randal O. Dull


This chapter discusses the genetics, metabolic actions, substrates, inducers, and inhibitors of cytochrome P450 2E1.


Cytochrome P450 Cytochrome CYP 2E1 CYP2E1 Pharmacokinetic Metabolism Metabolic pathway Enzyme Induction Inhibitor Substrate Oxidation Reduction Acetaminophen Alcohol Ethanol Alcohol dehydrogenase Alcohol-induced liver injury Lipid peroxidation Liver Hepatic Toxicology Isoniazid Halogenated anesthetics Enflurane Halothane Methoxyflurane Isoflurane Sevoflurane Desflurane Glutathione transferase N-acetyl transferase Aniline Ethylene glycol Nitrosamines Carbon tetrachloride Benzene Verapamil Disulfiram Trifluoroacetate Halothane hepatitis Polymorphisms 


  1. 1.
    Koop DR, Morgan ET, et al. Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. Chemistry. 1982;257:8472–80.Google Scholar
  2. 2.
    Koop DR. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J. 1992;6:724–30.PubMedGoogle Scholar
  3. 3.
    Kharasch ED, Thummel KE. Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993;79:795–807.PubMedCrossRefGoogle Scholar
  4. 4.
    Sun F, Chen Y. Drug-metabolising enzyme polymorphisms and predisposition to anti-tuberculosis drug-induced liver injury: a meta-analysis. Int J Tuberc Lung Dis. 2008;12(9):994–1002.PubMedGoogle Scholar
  5. 5.
    Sandson NB. Drug-Drug Interaction Primer: A Compendium of Case Vignettes for the Practicing Clinician. Arlington: American Psychiatric Publishing, Inc; 2007. p. 359–60.Google Scholar
  6. 6.
    Peter R, Baker R. Hydroxylation of chlorzoxazone as a specific probe for human liver CYP2E1. Chem Res Toxicol. 1990;3:566–73.PubMedCrossRefGoogle Scholar
  7. 7.
    Raucy JL, Lasker JM, et al. Induction of cytochrome P450IIE1 in the obese overfed rat. Molecul Pharmacol. 1991;39:275–80.Google Scholar
  8. 8.
    Lu Y, Cederbaum AI. CYP 2E1 and oxidative liver injury by alcohol. Free Radic Biol Med. 2008;44(5):723–38.PubMedPubMedCentralCrossRefGoogle Scholar
  9. 9.
    Chen TL, Uen TH, et al. Human cytochrome P450 mono-oxygenase system is suppressed by propofol. Br J Anaesth. 1995;74:558–62.PubMedCrossRefGoogle Scholar
  10. 10.
    Lejus C, Fautrel A, et al. Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002;64:1151–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnesthesiologyUniversity of Utah School of MedicineSalt Lake CityUSA
  2. 2.Department of AnesthesiologyUniversity of Illinois at ChicagoChicagoUSA

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