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Double Indemnity

Fatal Forty DDI: morphine, rifampin, P-glycoprotein

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A Case Approach to Perioperative Drug-Drug Interactions

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Abstract

This case discusses a pharmacokinetic drug interaction involving absorption and the P-glycoprotein (P-gp) transport system. Morphine is a P-gp substrate and rifampin is a P-gp inducer.

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References

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Author information

Authors and Affiliations

  1. Department of Pediatric Cardiac Anesthesiology, Memorial Regional Hospital, Hollywood, FL, USA

    Lisa Chan MD

  2. Anesthesia Services Department, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  3. Department of Psychiatry, University of Maryland Medical System, Baltimore, MD, USA

    Neil B. Sandson MD

  4. Department of Psychiatry, VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

  5. Department of Anesthesiology & Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD, FRCA, MCR

Authors
  1. Lisa Chan MD
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  2. Catherine Marcucci MD
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  3. Neil B. Sandson MD
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  4. Kirk Lalwani MD, FRCA, MCR
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Corresponding author

Correspondence to Lisa Chan MD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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© 2015 Springer Science+Business Media New York

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Chan, L., Marcucci, C., Sandson, N.B., Lalwani, K. (2015). Double Indemnity. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_58

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_58

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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