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Codeine Can’t Do It

Fatal Forty DDI: codeine, fluoxetine, CYP2D6

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A Case Approach to Perioperative Drug-Drug Interactions

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Abstract

This case discusses a pharmacokinetic interaction between the prodrug codeine and fluoxetine. Codeine is converted to its active metabolite morphine by cytochrome P450 2D6. Fluoxetine is a 2D6 inhibitor.

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References

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Author information

Authors and Affiliations

  1. Division of Neonatology, Clinical Hospital Merkur, Zagreb, Croatia

    Katarina Bojanić MD

  2. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Wayne T. Nicholson MD, PharmD, MSc, Erica D. Wittwer MD, PhD, Toby N. Weingarten MD & Juraj Sprung MD, PhD

  3. Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN, USA

    Toby N. Weingarten MD

Authors
  1. Katarina Bojanić MD
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  2. Wayne T. Nicholson MD, PharmD, MSc
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  3. Erica D. Wittwer MD, PhD
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  4. Toby N. Weingarten MD
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  5. Juraj Sprung MD, PhD
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Corresponding author

Correspondence to Katarina Bojanić MD .

Editor information

Editors and Affiliations

  1. Anesthesia Services Department, Philadelphia Veterans Affairs Med Center, Philadelphia, PA, USA

    Catherine Marcucci MD

  2. Department of Anesthesiology, Oregon Health and Science University, Portland, OR, USA

    Michael P. Hutchens MD

  3. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Erica D. Wittwer MD, PhD , Toby N. Weingarten MD , Juraj Sprung MD, PhD  & Wayne T. Nicholson MD, PharmD, MSc , ,  & 

  4. Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Kirk Lalwani MD

  5. Department of Anesthesiology, University of Pittsburgh School of Med Liliane S. Kaufmann Building, Pittsburgh, PA, USA

    David G. Metro MD

  6. Department of Anesthesiology, University of Illinois at Chicago, Chicago, IL, USA

    Randal O. Dull MD, PhD

  7. Department of Anesthesiology, Perioperative Medicine, Oregon Health and Science University, Portland, OR, USA

    Christopher E. Swide MD

  8. Department of Learning Health Sciences, University of Michigan Medical School, Ann Arbor, MI, USA

    F. Jacob Seagull PhD

  9. Department of Anesthesiology and Perioperative Medicine, Portland, OR, USA

    Jeffrey R. Kirsch MD (Professor and Chair) (Professor and Chair)

  10. Department of Psychiatry, University of Maryland Medical System VA Maryland Health Care System, Baltimore, MD, USA

    Neil B. Sandson MD

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© 2015 Springer Science+Business Media New York

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Bojanić, K., Nicholson, W.T., Wittwer, E.D., Weingarten, T.N., Sprung, J. (2015). Codeine Can’t Do It. In: Marcucci, C., et al. A Case Approach to Perioperative Drug-Drug Interactions. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7495-1_56

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  • DOI: https://doi.org/10.1007/978-1-4614-7495-1_56

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-7494-4

  • Online ISBN: 978-1-4614-7495-1

  • eBook Packages: MedicineMedicine (R0)

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