The Bawling Baby
This case discusses the pharmacokinetic interaction between methadone and rifampin resulting in methadone withdrawal symptoms. Methadone is a cytochrome P450 3A4 and 2B6 substrate and rifampin is a 3A4 and 2B6 inducer. Rifampin induces metabolism of methadone via 3A4 and 2B6 and can cause methadone withdrawal symptoms.
KeywordsPharmacokinetic Induction CYP3A4 CYP2B6 Methadone Rifampin Opioid Withdrawal Cytochrome P450 3A4 2B6