A Brief Treatise on the Area Under the Curve

  • Michael J. SikoraEmail author
  • Barbara Jericho


This chapter briefly discusses the pharmacologic parameter, commonly referred to as the Area Under the Curve, that describes the distribution and elimination of drugs from the body.


Area under the curve AUC One-compartment model Two-compartment model Drug bolus Elimination half-life Elimination phase Distribution phase Propofol Pharmacokinetic Bioavailability 

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnesthesiologyCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  2. 2.Department of AnesthesiologyUniversity of Illinois Hospital and Health Sciences System, University of Illinois-ChicagoChicagoUSA

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