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Triggering drugs, ryanodine receptor, malignant hyperthermia
  • Cornelius B. Groenewald
  • Juraj Sprung


This case discusses a drug–gene interaction. Administration of the triggering drugs isoflurane and succinylcholine interacted with a genetic variation of the ryanodine receptor causing malignant hyperthermia during general anesthesia.


Drug-gene interaction Pharmacgenomic Malignant hyperthermia MH Ryanodine receptor RYR1 Mutation Chromosome 19 Chromosome 7 Chromosome 1 Triggering agent Enflurane Methoxyflurane Isoflurane Sevoflurane Desflurane Halothane Succinylcholine Dantrolene Hypercapnia Metabolic acidosis Hyperkalemia Hypercalcemia Tachycardia Hypertension Hyperthermia Rigidity Calcium channel Sarcoplasmic reticulum Dihydropyridine receptor Autosomal dominant Malignant Hyperthermia Association of the United States 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Anesthesiology & Pain MedicineSeattle Children’s Hospital and the University of WashingtonSeattleUSA
  2. 2.Department of AnesthesiologyMayo ClinicRochesterUSA

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