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Pharmacodynamic Interactions: Core Concepts

  • Erica D. Wittwer
  • Wayne T. Nicholson

Abstract

This chapter discusses the essential terms and concepts pertaining to the relationship between the concentration of a drug at the end-organ site and the degree of drug effect. This subset of pharmacology is known as pharmacodynamics.

Keywords

Pharmacodynamics Pharmacokinetics Absorption Excretion Metabolism Distribution Dose-response curve Therapeutic window Ligand-receptor interaction Ligand affinity Receptor affinity Receptor specificity Diphenhydramine Efficacy Toxicity Ondansetron 5-hydroxytryptamine3 (5-HT3) receptor Agonism Antagonism Competitive binding Partial agonist Nondepolarizing neuromuscular blocking drugs Acetylcholine receptors Acetylcholinesterase Nicotinic receptor Muscarinic receptor Ceiling effect Cholinesterase inhibitor Phenoxybenzamine Ligand-gated ion channels G protein–coupled receptors Enzyme-linked receptors Intracellular receptors Opioid receptor (μυ οπιοιδ ρεχεπτορ, καππα οπιοιδ ρεχεπτορ, δ opioid receptor Substance P Dopamine Serotonin Histamine1 (H1Cannabinoid γ-aminobutyric acidB receptors GABAB NMDA receptors. Enzyme-linked natriuretic peptide receptor Epidermal growth factor receptor. Estrogen receptor Mineralocorticoid receptor Thyroid hormone receptors Tolerance Drug tolerance Cross-tolerance Addiction Dependance Tachyphylaxis Transdermal nitroglycerin Synergy Additive drug interaction Antagonistic drug interaction Infra-additive drug interaction Isoflurane Nitrous oxide 

Reference

  1. 1.
    Hendrickx JF, Eger 2nd EI, Sonner JM, et al. Is synergy the rule? A review of anesthetic interactions producing hypnosis and immobility. Anesth Analg. 2008;107:494–506.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnesthesiologyMayo ClinicRochesterUSA

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