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Desperate for a Drink

Fatal Forty DDI: amitriptyline, CYP2D6 poor metabolizer
  • Erica D. Wittwer
  • Juraj Sprung
  • Wayne T. Nicholson

Abstract

This case discusses a drug–gene interaction involving the poor metabolism of amitriptyline by the cytochrome P450 2D6 enzyme pathway, leading to toxicity.

Keywords

Drug-gene interaction Pharmacogenomic CYP2D6 Poor metabolizer Amitriptyline Tricyclic antidepressant Genetic variant 10-OH-nortriptyline Nortriptyline Toxicity Therapeutic window Anticholinergic QRS prolongation QTc prolongation Ventricular tachycardia Seizures CYP Cytochrome P450 2D6 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Erica D. Wittwer
    • 1
  • Juraj Sprung
    • 1
  • Wayne T. Nicholson
    • 1
  1. 1.Department of AnesthesiologyMayo ClinicRochesterUSA

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