Clopidogrel (II): Conferring over the Kung Pao

Clopidogrel, proton pump inhibitors, calcium channel blockers, CYP2C19, CYP3A4


This case further discusses the aggregation of risk factors for significant drug–drug interactions involving clopidogrel, proton pump inhibitors, and calcium channel blockers.


Pharmacokinetic Inhibitor Inhibition Clopidogrel Prodrug Platelet aggregation Antiplatelet effect Thrombosis Coronary artery stent Proton pump inhibitor Calcium channel blockers CYP3A4 CYP P450 Cytochrome 3A4 2C19 Verapamil Diltiazem CYP2C19 CYP2C19*2 More metabolizer Omeprazole Pantoprazole 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Anesthesia Services DepartmentPhiladelphia Veterans Affairs Medical CenterPhiladelphiaUSA
  2. 2.Department of PsychiatryUniversity of Maryland Medical SystemBaltimoreUSA
  3. 3.Department of PsychiatryVA Maryland Health Care SystemBaltimoreUSA

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