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Prazosin and the PTSD Paratrooper

Prazosin, tadalafil

Abstract

This case discusses α1-adrenergic blockade by prazosin and PDE 5-mediated hypotension by tadalafil in the presence of local anesthetic-induced sympathectomy

Keywords

Pharmacodynamic Prazosin Tadalafil Lidocaine Hypotension Local anesthetic Epidural Sympathectomy α1-adrenergic blockade Anti-hypertensive Post traumatic stress disorder PTSD Sexual dysfunction Nitric oxide NO Corpus cavernosum Phosphodiesterase type 5 PDE 5 CYP3A4 Sildenafil CYP 3A4 Cytochrome P450 

References

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    Prazosin [package insert]. New York: Pfizer Inc; 2004.Google Scholar
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    Hildago RB, Davidson JR. Posttraumatic stress disorder: epidemiology and health related considerations. J Clin Psychiatry. 2006;61 Suppl 7:5–13.Google Scholar
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    Miller LJ. Prazosin for the treatment of post traumatic stress disorder sleep disturbances. Pharmacotherapy. 2008;28(5):656–66.PubMedCrossRefGoogle Scholar
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    Tadalafil [package insert]. New York: Elli Lilly Inc.; 2005.Google Scholar
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    Klover RA. Pharmacology and drug interaction effects of the PDE 5 inhibitors: focus on alpha blocker interaction. Am J Cardiol. 2005;96 Suppl 2:42–6.Google Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Anesthesia and Critical CareUniversity of Chicago Pritzker School of MedicineChicagoUSA
  2. 2.Department of AnesthesiologyUniversity of Washington School of MedicineSeattleUSA

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