Prazosin and the PTSD Paratrooper

Prazosin, tadalafil


This case discusses α1-adrenergic blockade by prazosin and PDE 5-mediated hypotension by tadalafil in the presence of local anesthetic-induced sympathectomy


Pharmacodynamic Prazosin Tadalafil Lidocaine Hypotension Local anesthetic Epidural Sympathectomy α1-adrenergic blockade Anti-hypertensive Post traumatic stress disorder PTSD Sexual dysfunction Nitric oxide NO Corpus cavernosum Phosphodiesterase type 5 PDE 5 CYP3A4 Sildenafil CYP 3A4 Cytochrome P450 


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of Anesthesia and Critical CareUniversity of Chicago Pritzker School of MedicineChicagoUSA
  2. 2.Department of AnesthesiologyUniversity of Washington School of MedicineSeattleUSA

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