Advertisement

Seizures on 5 West

Carbapenem, valproic acid, P-glycoprotein, UGT

Abstract

This case discusses a complex interaction between valproic acid and carbapenem, resulting in decreased seizure threshold.

Keywords

Pharmacokinetic Valproate Valproic acid UGT UDP-glucuronosyltransferase p-glycoprotein Absorption Inhibitor Inhibition Carbapenem Imipenem 

References

  1. 1.
    Nagai K, Shimizu T, Togo A, et al. Decrease in serum levels of valproic acid during treatment with a new carbapenem, panipaenem/betamipron. J Antimicob Chemother. 1997;39:295–6.CrossRefGoogle Scholar
  2. 2.
    Llinares F, Bosacoma N, Hernandez C, et al. Pharmacokinetic interaction between valproic acid and carbapenem-like antibiotics. A discussion of three cases. Farm Hosp. 2003;27:258–63.Google Scholar
  3. 3.
    Lee SG, Kim JH, Joo JY, et al. Seven cases of decreased serum valproic acid concentration during concomitant use of carbapenem antibiotics. Korean J Lab Med. 2007;27(5):338–43.PubMedCrossRefGoogle Scholar
  4. 4.
    Radomynska-Pandya A, Czernik PJ, Little JM, et al. Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev. 1999;31:817–99.CrossRefGoogle Scholar
  5. 5.
    Yamamura N, Imura-Miyoshi K, Naganuma H. Panipenem, a carbapenem antibiotic, enhances the glucouronidation of intravenously administered valproic acid in rats. Drug Meta Dispos. 2000;27:724–30.Google Scholar
  6. 6.
    Mori H, Takahashi K, Mitzutani T. Interaction between valproic acid and carbapenem antibiotics. Drug Metab Rev. 2007;39:647–57.PubMedCrossRefGoogle Scholar
  7. 7.
    Yokogawa K, Iwashita S, Kubota A, et al. Effect of meropenem on disposition kinetics of valproate and its metabolites in rabbits. Pharm Res. 2001;18:1320–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Ogawa K, Yumoto R, Hamada N, et al. Interaction of valproic acid and carbapenam antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes. Epilepsy Res. 2006;71:76–87.PubMedCrossRefGoogle Scholar
  9. 9.
    Torii M, Takiguchi Y, Izumi M, et al. Carbapenem antibiotics inhibit valproic acid transport in Caco-2 cell monolayers. Int J Pharm. 2002;233:253–6.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnesthesiologyEmory University School of MedicineAtlantaUSA
  2. 2.Section of Orthopedic Anesthesiology, Department of Anesthesiology and Critical CareUniversity of PennsylvaniaWayneUSA

Personalised recommendations