Advertisement

Too Low To Go

Fatal Forty DDI: erythromycin, nifedipine, CYP3A4

Abstract

This case discusses a pharmacokinetic interaction between erythromycin and nifedipine resulting in postinduction hypotension. Nifedipine is a cytochrome P450 3A4 substrate and erythromycin is a 3A4 inhibitor.

Keywords

Pharmacokinetic Inhibitor Inhibition CYP3A4 Cytochrome CYP P450 3A4 Suicide inhibitor Irreversible inhibitor Erythromycin Nifedipine Antihypertensive Calcium channel blocker 

References

  1. 1.
    Iribane C, Dreano Y, Bardou LG, et al. Interaction of methadone with substrates of human hepatic cytochrome P450 3A4. Toxicology. 1997;117:13–23.CrossRefGoogle Scholar
  2. 2.
    Zhou S, Chan E, Lim LY, et al. Therapeutic drugs that behave as mechanism-based inhibitors of cytochrome P450 3A4. Curr Drug Metab. 2004;5(5):415–42.PubMedCrossRefGoogle Scholar
  3. 3.
    Greenblatt DJ, von Moltke LL, Harmatz JS, et al. Human cytochromes and some newer antidepressants: kinetics, metabolism, and drug interactions. J Clin Psychopharmacol. 1999;19(5 Suppl 1):23S–35.PubMedCrossRefGoogle Scholar
  4. 4.
    von Moltke LL, Greenblatt DJ, Court MH, et al. Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants. J Clin Psychopharmacol. 1995;15(2):125–31.CrossRefGoogle Scholar
  5. 5.
    Azaz-Livshits TL, Danenberg HD. Tachycardia, orthostatic hypotension and profound weakness due to concomitant use of fluoxetine and nifedipine. Pharmacopsychiatry. 1997;30(6):274–5.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Anesthesia Services DepartmentPhiladelphia Veterans Affairs Medical CenterPhiladelphiaUSA
  2. 2.Department of PsychiatryUniversity of Maryland Medical SystemBaltimoreUSA
  3. 3.Department of PsychiatryVA Maryland Health Care SystemBaltimoreUSA

Personalised recommendations