Too Low To Go

Fatal Forty DDI: erythromycin, nifedipine, CYP3A4


This case discusses a pharmacokinetic interaction between erythromycin and nifedipine resulting in postinduction hypotension. Nifedipine is a cytochrome P450 3A4 substrate and erythromycin is a 3A4 inhibitor.


Pharmacokinetic Inhibitor Inhibition CYP3A4 Cytochrome CYP P450 3A4 Suicide inhibitor Irreversible inhibitor Erythromycin Nifedipine Antihypertensive Calcium channel blocker 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Anesthesia Services DepartmentPhiladelphia Veterans Affairs Medical CenterPhiladelphiaUSA
  2. 2.Department of PsychiatryUniversity of Maryland Medical SystemBaltimoreUSA
  3. 3.Department of PsychiatryVA Maryland Health Care SystemBaltimoreUSA

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