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Tumor Oxygenation: An Appraisal of Past and Present Concepts and a Look into the Future

Arisztid G. B. Kovách Lecture

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Book cover Oxygen Transport to Tissue XXXV

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 789))

Abstract

Since 1970, the multifactorial pathogenesis of the deficient and heterogeneous oxygenation of transplanted murine tumors and of human cancers (including parameters determining oxygen delivery, e.g., blood flow, diffusion geometry, oxygen transport capacity of the blood) has been investigated in vivo. Hypoxia and/or anoxia was quantitatively assessed and characterized using microtechniques and special preclinical tumor models. Hypoxia subtypes were identified, and critical supply conditions were theoretically analyzed. In the 1980s, first experiments on humans were carried out in cancers of the rectum and of the oral cavity. In the 1990s, the clinical investigations were carried out on cancers of the breast and of the uterine cervix, clearly showing that hypoxia is a hallmark of locally advanced human tumors. In multivariate analysis, hypoxia was found to be an independent, adverse prognostic factor for patient survival due to hypoxia-driven malignant progression and hypoxia-associated resistance to anticancer therapy.

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Acknowledgments

The cooperation and excellent contribution of all research group members and colleagues to this research at the following institutions over the past 42 years is highly appreciated:

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Authors and Affiliations

  1. Department of Radiotherapy and Radiooncology, Klinikum rechts der Isar, Technical University, Ismaninger Strasse 22, 81675, Munich, Germany

    Peter Vaupel

Authors
  1. Peter Vaupel
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Correspondence to Peter Vaupel .

Editor information

Editors and Affiliations

  1. Department of Electrical Engineering and iMinds Future Health Department, KU Leuven, Leuven, Belgium

    Sabine Van Huffel  & Alexander Caicedo  & 

  2. Neonatal Intensive Care Unit KU Leuven, University Hospitals, Leuven, Belgium

    Gunnar Naulaers

  3. Synthesizer, Inc., Ellicott City, MD, USA

    Duane F. Bruley

  4. Microvascular Measurements, Lorenzen, Italy

    David K. Harrison

Appendix A Citation Record of Most-Cited Publications of Vaupel et al. (ISI Web of Science, August 21, 2012)

Appendix A Citation Record of Most-Cited Publications of Vaupel et al. (ISI Web of Science, August 21, 2012)

1705 × Vaupel et al (1989) Cancer Res 49: 6449

1018 × Höckel et al (1996) Cancer Res 56:4509

895 × Höckel & Vaupel (2001) J Natl Cancer Inst 93:268

618 × Vaupel et al (1991) Cancer Res 51:3316

518 × Höckel et al (1993) Radiother Oncol 26:45

320 × Vaupel & Mayer (2007) Cancer Metastasis Rev 26:225

315 × Vaupel et al (1981) Cancer Res 41:2008

289 × Höckel et al (1991) Cancer Res 51:6098

235 × Vaupel (2004) Semin Radiat Oncol 14:198

231 × Vaupel et al (2001) Semin Oncol 28 (suppl 8):29

220 × Höckel et al (1999) Cancer Res 59:4525

206 × Vaupel (2004) Oncologist 9 (suppl 5):10

205 × Vaupel et al (2001) Med Oncol 18:243

205 × Kallinowski et al (1990) Int J Radiat Oncol Biol Phys 19:953

204 × Tatum et al (2006) Int J Radiat Biol 82:699

203 × Höckel et al (1996) Semin Radiat Oncol 6:3

168 × Höckel & Vaupel (2001) Semin Oncol 28 (suppl 8)36

164 × Vaupel & Harrison (2002) Oncologist 9 (suppl 5):4

161 × Kallinowski et al (1989) Cancer Res 49:3759

– 150 × Bicher et al (1980) Radiology 137:523

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Vaupel, P. (2013). Tumor Oxygenation: An Appraisal of Past and Present Concepts and a Look into the Future. In: Van Huffel, S., Naulaers, G., Caicedo, A., Bruley, D.F., Harrison, D.K. (eds) Oxygen Transport to Tissue XXXV. Advances in Experimental Medicine and Biology, vol 789. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7411-1_31

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