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Skin Cancer pp 59-74 | Cite as

Molecular Pathology of Melanocytic Skin Cancer

  • Giuseppe PalmieriEmail author
  • Peter Sarantopoulos
  • Raymond Barnhill
  • Alistair Cochran
Chapter
Part of the Current Clinical Pathology book series (CCPATH)

Abstract

Characterization of the molecular mechanisms involved in the development and progression of melanoma could be helpful in identifying the pathogenetic profiles underlying both biological and clinical behaviors of the disease. Increasing evidence indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes, whose alterations are implicated in generating different subsets of melanoma patients with different prognoses and/or clinical outcomes. Knowledge of the main molecular features underlying the pathogenesis of melanoma is thus crucial for the development of new diagnostic and prognostic tools.

Keywords

Comparative Genomic Hybridization BRAF Mutation Primary Melanoma Uveal Melanoma Array Comparative Genomic Hybridization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Glossary

Molecular marker

Key molecular alteration which may help diagnosis, staging, and/or prognosis of cancer patients.

Target therapy

Treatment based on drugs specific for mutated/altered oncogenic protein playing a key role in molecular pathways involved in tumorigenesis.

Tumorigenesis

Induction of malignant transformation due to a complex combination of genetic and molecular alterations.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Giuseppe Palmieri
    • 1
    Email author
  • Peter Sarantopoulos
    • 2
  • Raymond Barnhill
    • 2
  • Alistair Cochran
    • 3
  1. 1.Department of Cancer GeneticsInstitute of Biomolecular Chemistry, National Research Council (CNR)SassariItaly
  2. 2.Department of Pathology and Laboratory MedicineDavid Geffen School of Medicine at UCLA, and Jonsson Comprehensive Cancer CenterLos AngelesUSA
  3. 3.Departments of Pathology, Laboratory Medicine and SurgeryDavid Geffen School of Medicine at UCLA, and Jonsson Comprehensive Cancer CenterLos AngelesUSA

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