Skin Cancer pp 487-497 | Cite as

Sentinel Lymph Node

  • Paolo Persichetti
  • Stefania Tenna
  • Beniamino BrunettiEmail author
  • Stefano Campa
Part of the Current Clinical Pathology book series (CCPATH)


The theory of lymphatic spread of cancer represents a basic chapter in the book of modern oncology. It was Cabanas (Cancer 39(2):456–466, 1977) in 1977 who introduced in the clinical practice the sentinel lymph node dissection (SLND) to stage penile carcinoma. Since those early efforts, many studies have clarified SLND’s crucial role in the staging of ectoderm-derived tumors, particularly in melanoma and breast cancer; anyway, the efficacy of SLN biopsy in the staging or treatment of nonmelanoma skin cancer has still to be proved.


Sentinel Lymph Node Sentinel Lymph Node Biopsy National Comprehensive Cancer Network Merkel Cell Carcinoma Clear Cell Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Handheld gamma probe

Radiation detector that provides a count rate from gamma rays and facilitates the intraoperative identification of radioactive lymph nodes.


Preoperative exam that allows to identify, by injecting a radioactive tracer in the site of primary neoplasm, nodal basins involved in the metastatic process.

Sentinel lymph node biopsy

Surgical identi fication of the first node involved in lymphatic spread of cancer through a small incision and a limited extent dissection.

Vital blue dye

Injection of a colored tracer in the site of primary neoplasm that complements lymphoscintigraphy and helps visualize the sentinel node during dissection.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Paolo Persichetti
    • 1
  • Stefania Tenna
    • 1
  • Beniamino Brunetti
    • 2
    Email author
  • Stefano Campa
    • 1
  1. 1.Plastic and Reconstructive Surgery UnitCampus Bio-Medico University of RomeRomeItaly
  2. 2.Plastic and Reconstructive Surgery UnitCampus Bio-Medico University of RomeRomeItaly

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