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Neutrophil Inflammation in COPD

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Smoking and Lung Inflammation

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Abstract

COPD is a disease of chronic inflammation which persists in patients after smoking cessation and intensifies as the disease progresses [1–3]. Patients with COPD, particularly those at risk for more frequent or severe exacerbations, exhibit an exaggerated innate immune response associated with elevated levels of inflammatory mediators and evidence of oxidative stress [1, 4–7]. Lung inflammation plays a key role in the pathophysiology of COPD and affects the airways, lung parenchyma, and pulmonary vasculature. Inflammation is not limited to the lung compartment. Systemic inflammation is an established feature of COPD, often accompanied by inflammation in the heart, blood vessels, and skeletal muscle which contribute significantly to disease morbidity and mortality [6, 8–10].

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Authors and Affiliations

  1. Center for Inflammation, Translational and Clinical Lung Research, Temple University School of Medicine, Philadelphia, PA, 19140, USA

    Paul A. Kennedy & Laurie E. Kilpatrick

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  1. Paul A. Kennedy
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  2. Laurie E. Kilpatrick
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Correspondence to Laurie E. Kilpatrick .

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  1. Center for Inflammation, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Thomas J. Rogers

  2. Department of Medicine & Pulmonary and Critical Care Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    Gerard J. Criner

  3. Center for Inflammation, Temple University School of Medicine, Philadelphia, Pennsylvania, USA

    William D. Cornwell

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Kennedy, P.A., Kilpatrick, L.E. (2013). Neutrophil Inflammation in COPD. In: Rogers, T., Criner, G., Cornwell, W. (eds) Smoking and Lung Inflammation. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7351-0_3

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