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Extracellular Potentials, Forward Modeling of

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Encyclopedia of Computational Neuroscience

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Definition

Forward modeling of extracellular potentials refers to the calculation of electrical potentials recorded inside or outside the brain due to activity in neuronal (and, if relevant, glial) sources. This contrasts the “inverse” problem which amounts to estimating the underlying neural sources from recorded potentials.

Detailed Description

Extracellular potentials recorded inside or outside the brain are generated by transmembrane currents from cells in the vicinity of the recording electrode. To propagate from the membrane to a recording electrode inside the brain, the signal has to pass through brain tissue consisting of a tightly packed matrix of neurons and glial cells embedded in the extracellular medium (Nunez and Srinivasan 2006). A well-founded biophysical forward-modeling scheme based on volume-conductor theory (Rall and Shepherd 1968; Holt and Koch 1999), incorporating detailed reconstructed neuronal morphologies, allows for precise calculations of extracellular...

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Authors and Affiliations

  1. Faculty of Science and Technology, Norwegian University of Life Sciences, Ås, Norway

    Gaute T. Einevoll

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  1. Gaute T. Einevoll
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Correspondence to Gaute T. Einevoll .

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  1. Atlanta, GA, USA

    Dieter Jaeger

  2. Department of Biomedical Engineering, Florida International University, Miami, FL, USA

    Ranu Jung

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  1. School of Psychology and Clinical Language Sciences, University of Reading, Reading, Whiteknights, UK

    Ingo Bojak Prof, PhD

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Einevoll, G.T. (2020). Extracellular Potentials, Forward Modeling of. In: Jaeger, D., Jung, R. (eds) Encyclopedia of Computational Neuroscience. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7320-6_59-2

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  • DOI: https://doi.org/10.1007/978-1-4614-7320-6_59-2

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Chapter history

  1. Latest

    Extracellular Potentials, Forward Modeling of
    Published:
    01 September 2020

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_59-2

  2. Original

    Extracellular Potentials, Forward Modeling of
    Published:
    07 February 2014

    DOI: https://doi.org/10.1007/978-1-4614-7320-6_59-1

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