Abstract
ABCA7 is a member of the ATP binding cassette transporter gene superfamily. These multispan transmembrane proteins are highly conserved and exist in organisms from bacteria to humans. Energy derived from the hydrolysis of ATP is used to transport a number of substrates across both the cellular and intracellular lipid membranes.
Apolipoprotein-dependent cholesterol efflux, sterol homeostasis and lipid metabolism can all be attributed to ABCA proteins to some degree, but how these roles manifest within the CNS and BBB is relatively unknown. Putative functionality within Alzheimer’s disease has been suggested for ABCA7 based on ABCA1 functionality and the observed homology between the proteins. Whilst cholesterol efflux is a minor role for ABCA7 there is a suggestion any reduction could hinder APOE lipidation. As lipidated APOE in the brain reduces Aβ accumulation, any inhibitor to this APOE lipidation could increase Aβ levels.
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Turton, J., Morgan, K. (2013). ATP-Binding Cassette, Subfamily A (ABC1), Member 7 (ABCA7). In: Morgan, K., Carrasquillo, M. (eds) Genetic Variants in Alzheimer's Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7309-1_7
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