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Erythropoietin-Producing Human Hepatocellular Carcinoma (EphA1)

  • Christopher Medway
  • Anne Braae
  • Kevin Morgan
Chapter

Abstract

Eph-like receptors belong to the receptor tyrosine kinase family and are divided into two classes, A and B, based on their extracellular domains and the ephrin ligands that they bind. Eph signalling is complex as the two classes of receptors can interact to form functional “clusters” and the receptors themselves are capable of signalling. EphA1 is expressed in multiple tissues and is involved in cell adhesion and organisation of a range of developmental and physiological processes. In the CNS, EphA1 is involved in neural development, synapse plasticity and dendritic spine morphogenesis, suggesting that these receptors may be important as modifiers of neurodegenerative disease. A polymorphism (rs11767557) 3,154 bp upstream of EPHA1 has been significantly associated with Alzheimer’s disease in Caucasian cohorts; however, the functional variant remains unknown. Ephrin receptor signalling operates on known AD pathology pathways. Some ephrin receptors require processing by γ–secretase, which has previously been linked to AD. Furthermore, the role of ephrin receptors in neurodevelopment and spine morphology in AD areas of the brain suggests that differences in neural circuitry may be at fault.

Keywords

Focal Adhesion Kinase Superior Colliculus EphA Receptor Spine Morphology Neural Stem Cell Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Human Genetics, School of Molecular Medical Sciences, Queen’s Medical CentreUniversity of NottinghamNottinghamUK

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