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More Topics About Escape from Immune Control

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War in the Body

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Abstract

A problem that has vexed vaccine developers in the HIV field is that some subjects make only a few CTL responses to HIV proteins, despite hundreds of know epitopes delivered by the injection. (In natural infection, the average number of responses is around 19; as many as 42 have been observed in a single patient.) Many theories have been elaborated for this surprising and, from the insights about escape arising from the Escape Formula, unfortunate phenomenon called “immunodominance”.

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Notes

  1. 1.

    It is commonly held that parasite and host adapt to each other, finally attaining a mutually-beneficial equilibrium; if so, this process implies diminishing virulence on the parasite’s part. But evolution must occur on both sides, by modulating reproduction and mortality, and so it requires many generations for both. There have not been a sufficient number of human generations since HIV entered the population for this scenario to have any plausibility.

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Authors and Affiliations

  1. Seattle, Washington, USA

    W. David Wick

  2. Geffen School of Medicine, Department of Medicine, UCLA Medical Center, Los Angeles, California, USA

    Otto O. Yang

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Wick, W.D., Yang, O.O. (2013). More Topics About Escape from Immune Control. In: War in the Body. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-7294-0_8

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