Afterword: The RV144 Trial and the Current Status of HIV Vaccine Research

  • W. David Wick
  • Otto O. Yang


The long history of vaccine development, starting with observations about cowpox and smallpox, has been mainly empirical. The two biggest pioneers of modern vaccines, Salk and Sabin, were proponents of two competing strategies: kill or weaken the pathogen, and mimic infection without disease.


Pretest Probability Uninfected Person Compete Strategy Modern Vaccine RV144 Trial 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • W. David Wick
    • 1
  • Otto O. Yang
    • 2
  1. 1.SeattleUSA
  2. 2.Geffen School of Medicine, Department of MedicineUCLA Medical CenterLos AngelesUSA

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